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   Hu H, Flynn N (August 2021, Proceedings of the National Academy of Sciences of the United States of America)

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2. Small Molecule Regulators Targeting NAD+ Biosynthetic Enzymes

   https://doi.org/10.2174/0929867328666210531144629  

   Curry, Alyson; White, Dawanna; Cen, Yana (May 2021, Current Medicinal Chemistry)

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   : Nicotinamide adenine dinucleotide (NAD + ) is a key player in many metabolic pathways as an activated carrier of electrons. In addition to being the cofactor for redox reactions, NAD + also serves as the substrate for various enzymatic transformations such as adenylation and ADP-ribosylation. Maintaining cellular NAD + homeostasis has been suggested as an effective anti-aging strategy. Given the importance of NAD + in regulating a broad spectrum of cellular events, small molecules targeting NAD + metabolism have been pursued as therapeutic interventions for the treatment of mitochondrial disorders and age-related diseases. In this article, small molecule regulators of NAD + biosynthetic enzymes will be reviewed. The focus will be given to the discovery and development of these molecules, the mechanism of action as well as their therapeutic potentials. 

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3. NAD+ Cleavage: TIR Domain-Containing Resistance Proteins in Action

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   Guberovic, Iva; Hurtado-Bagès, Sarah; Rivera-Casas, Ciro; Knobloch, Gunnar; Malinverni, Roberto; Valero, Vanesa; Leger, Michelle M.; García, Jesús; Basquin, Jerome; Gómez de Cedrón, Marta; et al (December 2021, Nature Structural & Molecular Biology)
5. Group 13 ion coordination to pyridyl models NAD ⁺ reduction potentials

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   Parsons, Leo_W T; Fettinger, James C; Berben, Louise A (July 2023, Chemical Communications)

   N-alkylation andN-metallation of pyridine are explored herein to understand how metal-ligand complexes can model NAD⁺redox chemistry. 

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