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Abstract PurposeTo examine the effect of incorporating self‐supervised denoising as a pre‐processing step for training deep learning (DL) based reconstruction methods on data corrupted by Gaussian noise. K‐space data employed for training are typically multi‐coil and inherently noisy. Although DL‐based reconstruction methods trained on fully sampled data can enable high reconstruction quality, obtaining large, noise‐free datasets is impractical. MethodsWe leverage Generalized Stein's Unbiased Risk Estimate (GSURE) for denoising. We evaluate two DL‐based reconstruction methods: Diffusion Probabilistic Models (DPMs) and Model‐Based Deep Learning (MoDL). We evaluate the impact of denoising on the performance of these DL‐based methods in solving accelerated multi‐coil magnetic resonance imaging (MRI) reconstruction. The experiments were carried out on T2‐weighted brain and fat‐suppressed proton‐density knee scans. ResultsWe observed that self‐supervised denoising enhances the quality and efficiency of MRI reconstructions across various scenarios. Specifically, employing denoised images rather than noisy counterparts when training DL networks results in lower normalized root mean squared error (NRMSE), higher structural similarity index measure (SSIM) and peak signal‐to‐noise ratio (PSNR) across different SNR levels, including 32, 22, and 12 dB for T2‐weighted brain data, and 24, 14, and 4 dB for fat‐suppressed knee data. ConclusionWe showed that denoising is an essential pre‐processing technique capable of improving the efficacy of DL‐based MRI reconstruction methods under diverse conditions. By refining the quality of input data, denoising enables training more effective DL networks, potentially bypassing the need for noise‐free reference MRI scans.
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Convolutional Neural Network Denoising of Focused Ion Beam Micrographs
Most research on deep learning algorithms for image denoising has focused on signal-independent additive noise. Focused ion beam (FIB) microscopy with direct secondary electron detection has an unusual Neyman Type A (compound Poisson) measurement model, and sample damage poses fundamental challenges in obtaining training data. Model-based estimation is difficult and ineffective because of the nonconvexity of the negative log likelihood. In this paper, we develop deep learning-based denoising methods for FIB micrographs using synthetic training data generated from natural images. To the best of our knowledge, this is the first attempt in the literature to solve this problem with deep learning. Our results show that the proposed methods slightly outperform a total variation-regularized model-based method that requires time-resolved measurements that are not conventionally available. Improvements over methods using conventional measurements and less accurate noise modeling are dramatic - around 10 dB in peak signal-to-noise ratio.
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- PAR ID:
- 10339854
- Date Published:
- Journal Name:
- IEEE 31st International Workshop on Machine Learning for Signal Processing (MLSP)
- Page Range / eLocation ID:
- 1 to 6
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Conference Paper:
- https://doi.org/10.1109/MLSP52302.2021.9596272
