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We study coherent anti-Stokes Raman spectroscopy in air-filled anti-resonance hollow-core photonic crystal fiber, otherwise known as “revolver” fiber. We compare the vibrational coherent anti-Stokes Raman signal of N 2 , at ∼2331 cm −1 , generated in ambient air (no fiber present), with the one generated in a 2.96 cm of a revolver fiber. We show a ∼170 times enhancement for the signal produced in the fiber, due to an increased interaction path. Remarkably, the N 2 signal obtained in the revolver fiber shows near-zero non-resonant background, due to near-zero overlap between the laser field and the fiber cladding. Through our study, we find that the revolver fiber properties make it an ideal candidate for the coherent Raman spectroscopy signal enhancement.
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On-demand nanozyme signal enhancement at the push of a button for the improved detection of SARS-CoV-2 nucleocapsid protein in serum
We developed an innovative 3D printed casing that incorporates a lateral-flow immunoassay, dehydrated signal enhancement reagents, and a sealed buffer chamber. With only the push of a button for signal enhancement, our device detected the SARS-CoV-2 N-protein in 40 min at concentrations as low as 0.1 ng mL −1 in undiluted serum.
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- Award ID(s):
- 1707194
- PAR ID:
- 10341102
- Date Published:
- Journal Name:
- The Analyst
- Volume:
- 146
- Issue:
- 24
- ISSN:
- 0003-2654
- Page Range / eLocation ID:
- 7386 to 7393
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.1039/d1an01350e
