- NSF-PAR ID:
- 10341549
- Date Published:
- Journal Name:
- Proceedings of the ACM on Interactive, Mobile, Wearable and Ubiquitous Technologies
- Volume:
- 6
- Issue:
- 2
- ISSN:
- 2474-9567
- Page Range / eLocation ID:
- 1 to 39
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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Abstract Social cognition may facilitate fathers' sensitive caregiving behavior. We administered the Why‐How Task, an fMRI task that elicits theory of mind processing, to expectant fathers (
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Background Dysregulation of the corticotropin‐releasing factor (
CRF ) system has been observed in rodent models of binge drinking, with a large focus onCRF receptor 1 (CRF ‐R1). The role ofCRF ‐binding protein (CRF ‐BP ), a key regulator ofCRF activity, in binge drinking is less well understood. In humans, single‐nucleotide polymorphisms in are associated with alcohol use disorder and stress‐induced alcohol craving, suggesting a role forCRHBP CRF ‐BP in vulnerability to alcohol addiction.Methods The role and regulation of
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CRF ‐BP mRNA expression in the mPFC , a region responsible for executive function and regulation of emotion and behavior, including responses to stress. We observed a persistent decrease inCRF ‐BP mRNA expression in the mPFC after 3 and 6DID cycles, which may allow for increasedCRF signaling atCRF ‐R1 and contribute to excessive binge‐like ethanol consumption. -
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Kazuhiro Maeshima (Ed.)
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