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Title: Synthesis of Ester-Substituted Indolizines from 2-Propargyloxypyridines and 1,3-Dicarbonyls
Two new complementary Au(I)-catalyzed methods for the preparation of ester-substituted indolizines from easily accessible 2-propargyloxypyridines and either acetoacetates or dimethyl malonate are reported. These reactions tolerate a wide range of functionality, allowing for diversification at three distinct positions of the product (R, R1, R2). For electron-poor substrates, the highest yields are observed upon reaction with acetoacetates, while neutral and electron-rich substrates give higher yields upon treatment with dimethyl malonate.  more » « less
Award ID(s):
1665139 1919565
NSF-PAR ID:
10343978
Author(s) / Creator(s):
; ; ; ; ;
Editor(s):
Miller, S.
Date Published:
Journal Name:
The Journal of Organic Chemistry
ISSN:
0022-3263
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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