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Title: Arylations with nitroarenes for one-pot syntheses of triaryl-methanols and tetraarylmethanes
Triarylmethanols are well-known core structures in natural products and pharmacologically relevant compounds. In general, transition metal-based catalysts or highly reactive organometallics are employed for the synthesis of these compounds. Herein, we report the regioselective tandem C(sp 3 )–H arylation/oxidation of diarylmethanes with nitroarenes to generate arylated alcohols. The present method is general, mild, green, and conducted in air at room temperature. Furthermore, use of triarylmethanes as pro-nucleophiles provides straightforward access to select tetraarylmethanes through a cross-dehydrogenative coupling process.  more » « less
Award ID(s):
1902509
NSF-PAR ID:
10348008
Author(s) / Creator(s):
; ; ; ; ; ; ; ;
Date Published:
Journal Name:
Organic Chemistry Frontiers
Volume:
9
Issue:
14
ISSN:
2052-4129
Page Range / eLocation ID:
3854 to 3861
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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