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Title: Reduced Graphene Oxide-Metalloporphyrin Sensors for Human Breath Screening
The objective of this study is to validate reduced graphene oxide (RGO)-based volatile organic compounds (VOC) sensors, assembled by simple and low-cost manufacturing, for the detection of disease-related VOCs in human breath using machine learning (ML) algorithms. RGO films were functionalized by four different metalloporphryins to assemble cross-sensitive chemiresistive sensors with different sensing properties. This work demonstrated how different ML algorithms affect the discrimination capabilities of RGO–based VOC sensors. In addition, an ML-based disease classifier was derived to discriminate healthy vs. unhealthy individuals based on breath sample data. The results show that our ML models could predict the presence of disease-related VOC compounds of interest with a minimum accuracy and F1-score of 91.7% and 83.3%, respectively, and discriminate chronic kidney disease breath with a high accuracy, 91.7%.  more » « less
Award ID(s):
1934568
PAR ID:
10349464
Author(s) / Creator(s):
; ;
Date Published:
Journal Name:
Applied Sciences
Volume:
11
Issue:
23
ISSN:
2076-3417
Page Range / eLocation ID:
11290
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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