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1. A Wide Planetary Mass Companion Discovered through the Citizen Science Project Backyard Worlds: Planet 9

   https://doi.org/10.3847/1538-4357/ac2499  

   Faherty, Jacqueline K. ; Gagné, Jonathan ; Popinchalk, Mark ; Vos, Johanna M. ; Burgasser, Adam J. ; Schümann, Jörg ; Schneider, Adam C. ; Kirkpatrick, J. Davy ; Meisner, Aaron M. ; Kuchner, Marc J. ; et al ( December 2021 , The Astrophysical Journal)

   Abstract Through the Backyard Worlds: Planet 9 citizen science project we discovered a late-type L dwarf co-moving with the young K0 star BD+60 1417 at a projected separation of 37″ or 1662 au. The secondary—CWISER J124332.12+600126.2 (W1243)—is detected in both the CatWISE2020 and 2MASS reject tables. The photometric distance and CatWISE proper motion both match that of the primary within ∼1 σ and our estimates for a chance alignment yield a zero probability. Follow-up near-infrared spectroscopy reveals W1243 to be a very red 2MASS ( J – K s = 2.72), low surface gravity source that we classify as L6–L8 γ . Its spectral morphology strongly resembles that of confirmed late-type L dwarfs in 10–150 Myr moving groups as well as that of planetary mass companions. The position on near- and mid-infrared color–magnitude diagrams indicates the source is redder and fainter than the field sequence, a telltale sign of an object with thick clouds and a complex atmosphere. For the primary we obtained new optical spectroscopy and analyzed all available literature information for youth indicators. We conclude that the Li i abundance, its loci on color–magnitude and color–color diagrams, and the rotation rate revealed in multiple TESS sectors are allmore »consistent with an age of 50–150 Myr. Using our re-evaluated age of the primary and the Gaia parallax, along with the photometry and spectrum for W1243, we find T eff = 1303 ± 31 K, log g = 4.3 ± 0.17 cm s −2 , and a mass of 15 ± 5 M Jup . We find a physical separation of ∼1662 au and a mass ratio of ∼0.01 for this system. Placing it in the context of the diverse collection of binary stars, brown dwarfs, and planetary companions, the BD+60 1417 system falls in a sparsely sampled area where the formation pathway is difficult to assess.« less
2. COol Companions ON Ultrawide orbiTS (COCONUTS). III. A Very Red L6 Benchmark Brown Dwarf around a Young M5 Dwarf

   https://doi.org/10.3847/1538-4357/ac7ce9  

   Zhang, Zhoujian ; Liu, Michael C. ; Morley, Caroline V. ; Magnier, Eugene A. ; Tucker, Michael A. ; Vanderbosch, Zachary P. ; Do, Aaron ; Shappee, Benjamin J. ( August 2022 , The Astrophysical Journal)

   Abstract We present the third discovery from the COol Companions ON Ultrawide orbiTS (COCONUTS) program, the COCONUTS-3 system, composed of the young M5 primary star UCAC4 374−046899 and the very red L6 dwarf WISEA J081322.19−152203.2. These two objects have a projected separation of 61 ′ ′ (1891 au) and are physically associated given their common proper motions and estimated distances. The primary star, COCONUTS-3A, has a mass of 0.123 ± 0.006 M ⊙ , and we estimate its age as 100 Myr to 1 Gyr based on its stellar activity (via H α and X-ray emission), kinematics, and spectrophotometric properties. We derive its bulk metallicity as 0.21 ± 0.07 dex using empirical calibrations established by older and higher-gravity M dwarfs and find that this [Fe/H] could be slightly underestimated according to PHOENIX models given COCONUTS-3A’s younger age. The companion, COCONUTS-3B, has a near-infrared spectral type of L6 ± 1 int-g , and we infer physical properties of T eff = 1362 − 73 + 48 K, log ( g ) = 4.96 − 0.34 + 0.15 dex, R = 1.03 − 0.06 + 0.12 R Jup , and M = 39 − 18 + 11 M Jup using its bolometricmore »luminosity, its host star’s age, and hot-start evolution models. We construct cloudy atmospheric model spectra at the evolution-based physical parameters and compare them to COCONUTS-3B’s spectrophotometry. We find that this companion possesses ample condensate clouds in its photosphere ( f sed = 1) with the data–model discrepancies likely due to the models using an older version of the opacity database. Compared to field-age L6 dwarfs, COCONUTS-3B has fainter absolute magnitudes and a 120 K cooler T eff . Also, the J − K color of this companion is among the reddest for ultracool benchmarks with ages older than a few hundred megayears. COCONUTS-3 likely formed in the same fashion as stellar binaries given the companion-to-host mass ratio of 0.3 and represents a valuable benchmark to quantify the systematics of substellar model atmospheres.« less
3. KMT-2021-BLG-0240: Microlensing event with a deformed planetary signal

   https://doi.org/10.1051/0004-6361/202243161  

   Han, Cheongho ; Kim, Doeon ; Yang, Hongjing ; Gould, Andrew ; Jung, Youn Kil ; Albrow, Michael D. ; Chung, Sun-Ju ; Hwang, Kyu-Ha ; Lee, Chung-Uk ; Ryu, Yoon-Hyun ; et al ( August 2022 , Astronomy & Astrophysics)

   Aims. The light curve of the microlensing event KMT-2021-BLG-0240 exhibits a short-lasting anomaly with complex features near the peak at the 0.1 mag level from a single-lens single-source model. We conducted modeling of the lensing light curve under various interpretations to reveal the nature of the anomaly. Methods. It is found that the anomaly cannot be explained with the usual model based on a binary-lens (2L1S) or a binary-source (1L2S) interpretation. However, a 2L1S model with a planet companion can describe part of the anomaly, suggesting that the anomaly may be deformed by a tertiary lens component or a close companion to the source. From the additional modeling, we find that all the features of the anomaly can be explained with either a triple-lens (3L1S) model or a binary-lens binary-source (2L2S) model. However, it is difficult to validate the 2L2S model because the light curve does not exhibit signatures induced by the source orbital motion and the ellipsoidal variations expected by the close separation between the source stars according to the model. We, therefore, conclude that the two interpretations cannot be distinguished with the available data, and either can be correct. Results. According to the 3L1S solution, the lens ismore »a planetary system with two sub-Jovian-mass planets in which the planets have masses of 0.32–0.47 M J and 0.44–0.93 M J , and they orbit an M dwarf host. According to the 2L2S solution, on the other hand, the lens is a single planet system with a mass of ~0.21 M J orbiting a late K-dwarf host, and the source is a binary composed of a primary of a subgiant or a turnoff star and a secondary of a late G dwarf. The distance to the planetary system varies depending on the solution: ~7.0 kpc according to the 3L1S solution and ~6.6 kpc according to the 2L2S solution.« less
4. Characterization of Monoclonal Antibody Glycan Heterogeneity Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry

   https://doi.org/10.3389/fbioe.2021.805788  

   Singh, Sumit K. ; Lee, Kelvin H. ( January 2022 , Frontiers in Bioengineering and Biotechnology)

   Glycosylation is a critical quality attribute of monoclonal antibody (mAb) therapeutics. Hydrophilic interaction liquid chromatography-mass spectrometry (HILIC-MS) is an invaluable technology for the characterization of protein glycosylation. HILIC/MS-based glycan analysis relies on the library search using Glucose Units (GU) and accurate mass (AM) as the primary search parameters for identification. However, GU-based identifications are gradient-dependent and are not suitable for applications where separation gradients need to be optimized to analyze complex samples or achieve higher throughput. Additionally, the workflow requires calibration curves (using dextran ladder) to be generated for each analysis campaign, which in turn, are used to derive the GU values of the separated glycan species. To overcome this limitation, we employed a two-step strategy for targeted glycan analysis of a mAb expressed in Chinese Hamster Ovary (CHO) cells. The first step is to create a custom library of the glycans of interest independent of GU values (thereby eliminating the need for a calibration curve) and instead uses AM and retention time (RT) as the primary search variables. The second step is to perform targeted glycan screening using the custom-built library. The developed workflow was applied for targeted glycan analysis of a mAb expressed in CHO for 1) cellmore »line selection 2) characterizing the day-wise glycan evolution in a model mAb during a fed-batch culture, 3) assessing the impact of different media conditions on glycosylation, and 4) evaluating the impact of two different process conditions on glycosylation changes in a model mAb grown in a bioreactor. Taken together, the data presented in this study provides insights into the sources of glycan heterogeneity in a model mAb that are seen during its commercial manufacturing.« less
5. The McDonald Accelerating Stars Survey: Architecture of the Ancient Five-planet Host System Kepler-444

   https://doi.org/10.3847/1538-3881/aca88c  

   Zhang, Zhoujian ; Bowler, Brendan P. ; Dupuy, Trent J. ; Brandt, Timothy D. ; Brandt, G. Mirek ; Cochran, William D. ; Endl, Michael ; MacQueen, Phillip J. ; Kratter, Kaitlin M. ; Isaacson, Howard T. ; et al ( January 2023 , The Astronomical Journal)

   We present the latest and most precise characterization of the architecture for the ancient (≈11 Gyr) Kepler-444 system, which is composed of a K0 primary star (Kepler-444 A) hosting five transiting planets and a tight M-type spectroscopic binary (Kepler-444 BC) with an A–BC projected separation of 66 au. We have measured the system’s relative astrometry using the adaptive optics imaging from Keck/NIRC2 and Kepler-444 A’s radial velocities from the Hobby-Eberly Telescope and reanalyzed relative radial velocities between BC and A from Keck/HIRES. We also include the Hipparcos-Gaia astrometric acceleration and all published astrometry and radial velocities in an updated orbit analysis of BC’s barycenter. These data greatly extend the time baseline of the monitoring and lead to significant updates to BC’s barycentric orbit compared to previous work, including a larger semimajor axis ($a={52.2}_{-2.7}^{+3.3}$au), a smaller eccentricity (e= 0.55 ± 0.05), and a more precise inclination ($i=85.°4_{-0.°4}^{+0.°3}$). We have also derived the first dynamical masses of B and C components. Our results suggest that Kepler-444 A’s protoplanetary disk was likely truncated by BC to a radius of ≈8 au, which resolves the previously noticed tension between Kepler-444 A’s disk mass and planet masses. Kepler-444more »BC’s barycentric orbit is likely aligned with those of A’s five planets, which might be primordial or a consequence of dynamical evolution. The Kepler-444 system demonstrates that compact multiplanet systems residing in hierarchical stellar triples can form at early epochs of the universe and survive their secular evolution throughout cosmic time.

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