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The biocompatibility of materials used in electronic devices is critical for the development of implantable devices like pacemakers and neuroprosthetics, as well as in future biomanufacturing. Biocompatibility refers to the ability of these materials to interact with living cells and tissues without causing an adverse response. Therefore, it is essential to evaluate the biocompatibility of metals and semiconductor materials used in electronic devices to ensure their safe use in medical applications. Here, we evaluated the biocompatibility of a collection of diced silicon chips coated with a variety of metal thin films, interfacing them with different cell types, including murine mastocytoma cells in suspension culture, adherent NIH 3T3 fibroblasts, and human induced pluripotent stem cell (iPSC)-derived neural progenitor cells (NPCs). All materials tested were biocompatible and showed the potential to support neural differentiation of iPSC-NPCs, creating an opportunity to use these materials in a scalable production of a range of biohybrid devices such as electronic devices to study neural behaviors and neuropathies.
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Biocompatible and Nanoenabled Technologies for Biological Modulation
Abstract Biocompatible and nanoscale devices for biological modulation of cells and tissues possess the potential for tremendous impact on medical and industrial technologies. Typical medical devices and therapies tend to be macroscale, comprised of nonbiocompatible materials, and broadly targeted, resulting in imprecise treatments and adverse effects such as chronic immune response and tissue damage. The development of nanoenabled and biocompatible technologies—ranging from biodegradable nanoparticles for localized drug delivery to transient electronic devices for stimulation therapy to engineered biofilms with applications to nanomedicine—will continue to enable the advent of personalized medicine and precision therapies. In this review, recent research into this frontier is reviewed, first analyzing the synthesis of nanoenabled and biocompatible technologies and then presenting significant considerations regarding the development of such materials. Lastly, the latest advancements in biocompatible, nanoenabled devices are examined, followed by a discussion of the direction of future research in the field.
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- PAR ID:
- 10367353
- Publisher / Repository:
- Wiley Blackwell (John Wiley & Sons)
- Date Published:
- Journal Name:
- Advanced Materials Technologies
- Volume:
- 7
- Issue:
- 2
- ISSN:
- 2365-709X
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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