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Title: A Highly Water‐ and Air‐Stable Iron‐Containing MRI Contrast Agent Sensor for H 2 O 2
Abstract A highly water‐ and air‐stable Fe(II) complex with the quinol‐containing macrocyclic ligand H4qp4 reacts with H2O2to yield Fe(III) complexes with less highly chelating forms of the ligand that have either one or twopara‐quinones. The reaction increases theT1‐weighted relaxivity over four‐fold, enabling the complex to detect H2O2using clinical MRI technology. The iron‐containing sensor differs from its recently characterized manganese analog, which also detects H2O2, in that it is the oxidation of the metal center, rather than the ligand, that primarily enhances the relaxivity.  more » « less
Award ID(s):
1954336 1662875
PAR ID:
10369666
Author(s) / Creator(s):
 ;  ;  ;  ;  ;  ;  ;  ;  
Publisher / Repository:
Wiley Blackwell (John Wiley & Sons)
Date Published:
Journal Name:
Chemistry – A European Journal
Volume:
28
Issue:
46
ISSN:
0947-6539
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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