skip to main content
US FlagAn official website of the United States government
dot gov icon
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
https lock icon
Secure .gov websites use HTTPS
A lock ( lock ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Explore Research Products in the PAR
It may take a few hours for recently added research products to appear in PAR search results.


Title: Decoherence of photon entanglement by transmission through brain tissue with Alzheimer’s disease
The generation, manipulation and quantification of non-classical light, such as quantum-entangled photon pairs, differs significantly from methods with classical light. Thus, quantum measures could be harnessed to give new information about the interaction of light with matter. In this study we investigate if quantum entanglement can be used to diagnose disease. In particular, we test whether brain tissue from subjects suffering from Alzheimer’s disease can be distinguished from healthy tissue. We find that this is indeed the case. Polarization-entangled photons traveling through brain tissue lose their entanglement via a decohering scattering interaction that gradually renders the light in a maximally mixed state. We found that in thin tissue samples (between 120 and 600 micrometers) photons decohere to a distinguishable lesser degree in samples with Alzheimer’s disease than in healthy-control ones. Thus, it seems feasible that quantum measures of entangled photons could be used as a means to identify brain samples with the neurodegenerative disease.  more » « less
Award ID(s):
2011937
PAR ID:
10381542
Author(s) / Creator(s):
; ; ; ; ; ; ; ; ; ;
Publisher / Repository:
Optical Society of America
Date Published:
Journal Name:
Biomedical Optics Express
Volume:
13
Issue:
12
ISSN:
2156-7085
Format(s):
Medium: X Size: Article No. 6621
Size(s):
Article No. 6621
Sponsoring Org:
National Science Foundation
More Like this
  1. ; ; ; ; ; (, Proceedings of SPIE)
    Andrews, D.; Galvez, EJ; Rubinsztein-Dunlop, H. (Ed.)
    There is interest in using photon entanglement in biomedical applications. In one application, polarization-entangled photons pass through brain tissue. The effect of the brain tissue on the photon entanglement is measured via the decoherence that is imparted on the entangled state. Our current method to obtain a measure of the decoherence involves quantum state tomography, where a minimum of 16 measurements are used in conjunction with tomographic optimization to obtain the density matrix representing the state of the photons. In this work we report on a method to avoid tomographic optimization on behalf of a direct measurement of the elements of the density matrix. We make preliminary comparisons between the two methods. 
    more » « less
  2. ; ; ; ; ; (, Laser & Photonics Reviews)
    Abstract Pathway selectivity in quantum spectroscopy with entangled photons is a powerful spectroscopic tool. Phase‐matched signals involving classical light contain contributions from multiple material pathways, whereas quantum spectroscopy may allow the selection of individual pathways. 2D electronic‐vibrational spectroscopy (2DEVS) is a four‐wave mixing technique which employs visible and infrared entangled photons. It is showed how the three contributing pathways—ground state bleach, excited state absorption, and excited state emission—can be separated by photon‐number‐resolved coincidence measurements. Entangled photons thus reveal spectral features not visible in the classical signal, with an enhanced spectral resolution. 
    more » « less
  3. ; ; ; ; ; (, Nature Physics)
    Correlations between entangled photons are a key ingredient for testing fundamental aspects of quantum mechanics and an invaluable resource for quantum technologies. However, scattering from a dynamic medium typically scrambles and averages out such correlations. Here we show that multiply scattered entangled photons reflected from a dynamic complex medium remain partially correlated. In experiments and full-wave simulations we observe enhanced correlations, within an angular range determined by the transport mean free path, which prevail over disorder averaging. Theoretical analysis reveals that this enhancement arises from the interference between scattering trajectories, in which the photons leave the sample and are then virtually reinjected back into it. These paths are the quantum counterpart of the paths that lead to the coherent backscattering of classical light. This work points to opportunities for entanglement transport despite dynamic multiple scattering in complex systems. 
    more » « less
  4. ; ; ; ; ; (, Proceedings of the National Academy of Sciences)
    Multiphoton absorption of entangled photons offers ways for obtaining unique information about chemical and biological processes. Measurements with entangled photons may enable sensing biological signatures with high selectivity and at very low light levels to protect against photodamage. In this paper, we present a theoretical and experimental study of the excitation wavelength dependence of the entangled two-photon absorption (ETPA) process in a molecular system, which provides insights into how entanglement affects molecular spectra. We demonstrate that the ETPA excitation spectrum can be different from that of classical TPA as well as that for one-photon resonant absorption (OPA) with photons of doubled frequency. These results are modeled by assuming the ETPA cross-section is governed by a two-photon excited state radiative linewidth rather than by electron-phonon interactions, and this leads to excitation spectra that match the observed results. Further, we find that the two-photon-allowed states with highest TPA and ETPA intensities have high electronic entanglements, with ETPA especially favoring states with the longest radiative lifetimes. These results provide concepts for the development of quantum light–based spectroscopy and microscopy that will lead to much higher efficiency of ETPA sensors and low-intensity detection schemes. 
    more » « less
  5. ; (, Applied Sciences)
    Polarization-sensitive quantum optical coherence tomography (PS-QOCT) is used to image and characterize birefringence effects in biological samples. Entangled photons are generated via spontaneous parametric down-conversion and split into a reference arm and a sample arm of a Mach Zehnder interferometer. Interferometric patterns between two entangled photons reveal information about tissue birefringence. Biological tissue samples are imaged and characterized, and their quantum interference patterns and birefringence profiles are presented. 
    more » « less
  • Citation Formats
  • MLA
  • APA
  • Chicago
  • BibTeX
  • Save / Share this Record
  • Send to Email