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Title: The dual nature of the nucleolus
The nucleolus is best known for housing the highly ordered assembly line that produces ribosomal subunits. The >100 ribosome assembly factors in the nucleolus are thought to cycle between two states: an operative state (when integrated into subunit assembly intermediates) and a latent state (upon release from intermediates). Although it has become commonplace to refer to the nucleolus as “being a multilayered condensate,” and this may be accurate for latent factors, there is little reason to think that such assertions pertain to the operative state of assembly factors.  more » « less
Award ID(s):
2141390
PAR ID:
10385882
Author(s) / Creator(s):
; ; ; ; ;
Date Published:
Journal Name:
Genes & Development
Volume:
36
Issue:
13-14
ISSN:
0890-9369
Page Range / eLocation ID:
765 to 769
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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