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Summary We consider scenarios in which the likelihood function for a semiparametric regression model factors into separate components, with an efficient estimator of the regression parameter available for each component. An optimal weighted combination of the component estimators, named an ensemble estimator, may be employed as an overall estimate of the regression parameter, and may be fully efficient under uncorrelatedness conditions. This approach is useful when the full likelihood function may be difficult to maximize, but the components are easy to maximize. It covers settings where the nuisance parameter may be estimated at different rates in the component likelihoods. As a motivating example we consider proportional hazards regression with prospective doubly censored data, in which the likelihood factors into a current status data likelihood and a left-truncated right-censored data likelihood. Variable selection is important in such regression modelling, but the applicability of existing techniques is unclear in the ensemble approach. We propose ensemble variable selection using the least squares approximation technique on the unpenalized ensemble estimator, followed by ensemble re-estimation under the selected model. The resulting estimator has the oracle property such that the set of nonzero parameters is successfully recovered and the semiparametric efficiency bound is achieved for this parameter set. Simulations show that the proposed method performs well relative to alternative approaches. Analysis of an AIDS cohort study illustrates the practical utility of the method.
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A note on centering in subsample selection for linear regression
Centring is a commonly used technique in linear regression analysis. With centred data on both the responses and covariates, the ordinary least squares estimator of the slope parameter can be calculated from a model without the intercept. If a subsample is selected from a centred full data, the subsample is typically uncentred. In this case, is it still appropriate to fit a model without the intercept? The answer is yes, and we show that the least squares estimator on the slope parameter obtained from a model without the intercept is unbiased and it has a smaller variance covariance matrix in the Loewner order than that obtained from a model with the intercept. We further show that for noninformative weighted subsampling when a weighted least squares estimator is used, using the full data weighted means to relocate the subsample improves the estimation efficiency.
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- Award ID(s):
- 2105571
- PAR ID:
- 10387850
- Publisher / Repository:
- Wiley Blackwell (John Wiley & Sons)
- Date Published:
- Journal Name:
- Stat
- Volume:
- 11
- Issue:
- 1
- ISSN:
- 2049-1573
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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