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Title: Bacillus subtilis Cell Differentiation, Biofilm Formation and Environmental Prevalence
Bacillus subtilis is a soil-dwelling, spore-forming Gram-positive bacterium capable of cell differentiation. For decades, B. subtilis has been used as a model organism to study development of specialized cell types. In this minireview, we discuss cell differentiation in B. subtilis, covering both past research and recent progresses, and the role of cell differentiation in biofilm formation and prevalence of this bacterium in the environment. We review B. subtilis as a classic model for studies of endospore formation, and highlight more recent investigations on cell fate determination and generation of multiple cell types during biofilm formation. We present mechanistic details of how cell fate determination and mutually exclusive cell differentiation are regulated during biofilm formation.  more » « less
Award ID(s):
1651732
PAR ID:
10389232
Author(s) / Creator(s):
; ;
Date Published:
Journal Name:
Microorganisms
Volume:
10
Issue:
6
ISSN:
2076-2607
Page Range / eLocation ID:
1108
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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