Optical coherence microscopy (OCM) uses interferometric detection to capture the complex optical field with high sensitivity, which enables computational wavefront retrieval using backscattered light from the sample. Compared to a conventional wavefront sensor, aberration sensing with OCM via computational adaptive optics (CAO) leverages coherence and confocal gating to obtain signals from the focus with less crosstalk from other depths or transverse locations within the fieldofview. Here, we present an investigation of the performance of CAObased aberration sensing in simulation, bead phantoms, and
Fourier ptychographic microscopy is a computational imaging technique that provides quantitative phase information and high resolution over a large fieldofview. Although the technique presents numerous advantages over conventional microscopy, model mismatch due to unknown optical aberrations can significantly limit reconstruction quality. A practical way of correcting for aberrations without additional data capture is through algorithmic selfcalibration, in which a pupil recovery step is embedded into the reconstruction algorithm. However, softwareonly aberration correction is limited in accuracy. Here, we evaluate the merits of implementing a simple, dedicated calibration procedure for applications requiring high accuracy. In simulations, we find that for a target sample reconstruction error, we can image without any aberration corrections only up to a maximum aberration magnitude of
 NSFPAR ID:
 10389533
 Publisher / Repository:
 Optical Society of America
 Date Published:
 Journal Name:
 Optics Continuum
 Volume:
 2
 Issue:
 1
 ISSN:
 27700208
 Page Range / eLocation ID:
 Article No. 119
 Format(s):
 Medium: X
 Sponsoring Org:
 National Science Foundation
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ex vivo mouse brain tissue. We demonstrate that, due to the influence of the doublepass confocal OCM imaging geometry on the shape of computed pupil functions, computational sensing of highorder aberrations can suffer from signal attenuation in certain spatialfrequency bands and shape similarity with lower order counterparts. However, by sensing and correcting only loworder aberrations (astigmatism, coma, and trefoil), we still successfully corrected tissueinduced aberrations, leading to 3× increase in OCM signal intensity at a depth of ∼0.9 mm in a freshly dissectedex vivo mouse brain. 
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