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Title: Structure and Formation of Z-DNA and Z-RNA
Despite structural differences between the right-handed conformations of A-RNA and B-DNA, both nucleic acids adopt very similar, left-handed Z-conformations. In contrast to their structural similarities and sequence preferences, RNA and DNA exhibit differences in their ability to adopt the Z-conformation regarding their hydration shells, the chemical modifications that promote the Z-conformation, and the structure of junctions connecting them to right-handed segments. In this review, we highlight the structural and chemical properties of both Z-DNA and Z-RNA and delve into the potential factors that contribute to both their similarities and differences. While Z-DNA has been extensively studied, there is a gap of knowledge when it comes to Z-RNA. Where such information is lacking, we try and extend the principles of Z-DNA stability and formation to Z-RNA, considering the inherent differences of the nucleic acids.  more » « less
Award ID(s):
2153787
PAR ID:
10407282
Author(s) / Creator(s):
; ; ; ;
Date Published:
Journal Name:
Molecules
Volume:
28
Issue:
2
ISSN:
1420-3049
Page Range / eLocation ID:
843
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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