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The integration of molecular robots and synthetic biology allows for the creation of sophisticated behaviors at the molecular level. Similar to the synergy between bioelectronics and soft robotics, synthetic biology provides control circuitry for molecular robots. By encoding perception-action modules within synthetic circuits, molecular machines can advance beyond repeating tasks to the incorporation of complex behaviors. In particular, cell-free synthetic biology provides biomolecular circuitry independent of living cells. This research update reviews the current progress in using synthetic biology as perception-action control modules in robots from molecular robots to macroscale robots. Additionally, it highlights recent developments in molecular robotics and cell-free synthetic biology and suggests their combined use as a necessity for future molecular robot development.
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Engineering the Future through Synthetic Biology
The last two decades have witnessed tremendous progress in synthetic biology. Despite the technological advances, the maturing field has yet to transition from fundamental study to translational practice. In this perspective article, I discuss my vision to enable this transition. With this vision, our next generation will solve global problems through synthetic biology.
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- Award ID(s):
- 2001743
- PAR ID:
- 10414744
- Date Published:
- Journal Name:
- Biotechnology and Bioprocess Engineering
- ISSN:
- 1226-8372
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.1007/s12257-022-0191-9
