An official website of the United States government
The integration of molecular robots and synthetic biology allows for the creation of sophisticated behaviors at the molecular level. Similar to the synergy between bioelectronics and soft robotics, synthetic biology provides control circuitry for molecular robots. By encoding perception-action modules within synthetic circuits, molecular machines can advance beyond repeating tasks to the incorporation of complex behaviors. In particular, cell-free synthetic biology provides biomolecular circuitry independent of living cells. This research update reviews the current progress in using synthetic biology as perception-action control modules in robots from molecular robots to macroscale robots. Additionally, it highlights recent developments in molecular robotics and cell-free synthetic biology and suggests their combined use as a necessity for future molecular robot development.
more »
« less
Engineering the Future through Synthetic Biology
The last two decades have witnessed tremendous progress in synthetic biology. Despite the technological advances, the maturing field has yet to transition from fundamental study to translational practice. In this perspective article, I discuss my vision to enable this transition. With this vision, our next generation will solve global problems through synthetic biology.
more »
« less
- Award ID(s):
- 2001743
- PAR ID:
- 10414744
- Date Published:
- Journal Name:
- Biotechnology and Bioprocess Engineering
- ISSN:
- 1226-8372
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
More Like this
-
-
Abstract Living systems contain various membraneless organelles that segregate proteins and RNAs via liquid–liquid phase separation. Inspired by nature, many protein-based synthetic compartments have been engineered in vitro and in living cells. Here, we introduce a genetically encoded CAG-repeat RNA tag to reprogram cellular condensate formation and recruit various non-phase-transition RNAs for cellular modulation. With the help of fluorogenic RNA aptamers, we have systematically studied the formation dynamics, spatial distributions, sizes and densities of these cellular RNA condensates. The cis- and trans-regulation functions of these CAG-repeat tags in cellular RNA localization, life time, RNA–protein interactions and gene expression have also been investigated. Considering the importance of RNA condensation in health and disease, we expect that these genetically encodable modular and self-assembled tags can be widely used for chemical biology and synthetic biology studies.more » « less
-
Abstract Online video resources have increasingly become a common way to effectively share scientific research ideas and engage viewers at many levels of interest or expertise. While synthetic biology is a comparatively young field, it has accumulated online videos across a spectrum of content and technical depth. Such video content can be used to introduce viewers to synthetic biology, supplement college course content, teach new lab skills and entertain. Here, we compile online videos concerning synthetic biology into public YouTube playlists tailored for six different, though potentially overlapping, audiences: those wanting an introduction to synthetic biology, those wanting to get quick overviews of specific topics within synthetic biology, those wanting teaching or public lectures, those wanting more technical research lectures, those wanting to learn lab protocols and those interested in the International Genetically Engineered Machine competition.more » « less
-
The development of synthetic, metal-based catalysts to perform intracellular bioorthogonal reactions represents a relatively new and important area of research that combines transition metal catalysis and chemical biology. The ability to perform reactions in cellulo , especially those transformations without a natural counterpart, offers a versatile tool for medicinal chemists and chemical biologists. With proper modification of the metal catalysts, it is even possible to direct a reaction to certain intracellular sites. This review highlights advances in this new area, from early work on intracellular functional group conversions to recent advances in intracellular synthesis of drugs, including cytotoxic agents. Both the fundamental and applied aspects of this approach to intracellular synthesis are reviewed.more » « less
-
This is a chapter in Book "Distributed Computing by Mobile Entities: Current Research in Moving and Computing", Springer Nature. The vision for programmable matter is to realize a physical substance that is scalable, versatile, instantly reconfigurable, safe to handle, and robust to failures. Programmable matter could be deployed in a variety of domain spaces to address a wide gamut of problems, including applications in construction, environmental science, synthetic biology, and space exploration. However, there are considerable engineering and computational challenges that must be overcome before such a system could be implemented. Towards developing efficient algorithms for novel programmable matter behaviors, the amoebot model for self-organizing particle systems and its variant, hybrid programmable matter, provide formal computational frameworks that facilitate rigorous algorithmic research. In this chapter, we discuss distributed algorithms under these models for shape formation, shape recognition, object coating, compression, shortcut bridging, and separation in addition to some underlying algorithmic primitives.more » « less
- Free Publicly Accessible Full Text
-
Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.1007/s12257-022-0191-9
