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1. i B io S im 3: A Tool for Model-Based Genetic Circuit Design

   https://doi.org/10.1021/acssynbio.8b00078  

   Watanabe, Leandro ; Nguyen, Tramy ; Zhang, Michael ; Zundel, Zach ; Zhang, Zhen ; Madsen, Curtis ; Roehner, Nicholas ; Myers, Chris ( July 2018 , ACS Synthetic Biology)
2. Genetic diversity in S vaneti and its implications for the human settlement of the H ighland C aucasus

   https://doi.org/10.1002/ajpa.23324  

   Yardumian, Aram ; Shengelia, Ramaz ; Chitanava, David ; Laliashvili, Shorena ; Bitadze, Lia ; Laliashvili, Irma ; Villanea, Fernando ; Sanders, Akiva ; Azzam, Andrew ; Groner, Victoria ; et al ( October 2017 , American Journal of Physical Anthropology)
3. Genetic and physical interactions between the organellar mechanosensitive ion channel homologs MSL 1, MSL 2, and MSL 3 reveal a role for inter‐organellar communication in plant development

   https://doi.org/10.1002/pld3.124  

   Lee, Josephine S. ; Wilson, Margaret E. ; Richardson, Ryan A. ; Haswell, Elizabeth S. ( March 2019 , Plant Direct)

   Plant development requires communication on many levels, including between cells and between organelles within a cell. For example, mitochondria and plastids have been proposed to be sensors of environmental stress and to coordinate their responses. Here we present evidence for communication between mitochondria and chloroplasts during leaf and root development, based on genetic and physical interactions between threeMechanosensitive channel ofSmall conductance‐Like (MSL) proteins fromArabidopsis thaliana.MSLproteins areArabidopsishomologs of the bacterialMechanosensitivechannel ofSmall conductance (MscS), which relieves cellular osmotic pressure to protect against lysis during hypoosmotic shock.MSL1 localizes to the inner mitochondrial membrane, whileMSL2 andMSL3 localize to the inner plastid membrane and are required to maintain plastid osmotic homeostasis during normal growth and development. In this study, we characterized the phenotypic effect of a genetic lesion inMSL1, both in wild type and inmsl2 msl3mutant backgrounds.msl1single mutants appear wild type for all phenotypes examined. The characteristic leaf rumpling inmsl2 msl3double mutants was exacerbated in themsl1 msl2 msl3triple mutant. However, the introduction of themsl1lesion into themsl2 msl3mutant background suppressed othermsl2 msl3mutant phenotypes, including ectopic callus formation, accumulation of superoxide and hydrogen peroxide in the shoot apical meristem, decreased root length, and reduced number of lateral roots. All thesemore »phenotypes could be recovered by molecular complementation with a transgene containing a wild type version ofMSL1. In yeast‐based interaction studies,MSL1 interacted with itself, but not withMSL2 orMSL3. These results establish that the abnormalities observed inmsl2 msl3double mutants is partially dependent on the presence of functionalMSL1 and suggest a possible role for communication between plastid and mitochondria in seedling development.

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4. Phylogeography of Pogonomyrmex barbatus and P. rugosus harvester ants with genetic and environmental caste determination

   https://doi.org/10.1002/ece3.1507  

   Mott, Brendon M. ; Gadau, Jürgen ; Anderson, Kirk E. ( June 2015 , Ecology and Evolution)
5. Genetic contributions to dental dimensions in brown‐mantled tamarins ( Saguinus fuscicollis ) and rhesus macaques ( Macaca mulatta )

   https://doi.org/10.1002/ajpa.23744  

   Hardin, Anna M. ( December 2018 , American Journal of Physical Anthropology)

   The use of dental metrics in phylogenetic reconstructions of fossil primates assumes variation in tooth size is highly heritable. Quantitative genetic studies in humans and baboons have estimated high heritabilities for dental traits, providing a preliminary view of the variability of dental trait heritability in nonhuman primate species. To expand upon this view, the heritabilities and evolvabilities of linear dental dimensions are estimated in brown‐mantled tamarins (Saguinus fuscicollis) and rhesus macaques (Macaca mulatta).

   Quantitative genetic analyses were performed on linear dental dimensions collected from 302 brown‐mantled tamarins and 364 rhesus macaques. Heritabilities were estimated in SOLAR using pedigrees from each population, and evolvabilities were calculated manually.

   Tamarin heritability estimates range from 0.19 to 0.99, and 25 of 26 tamarin estimates are significantly different from zero. Macaque heritability estimates range from 0.08 to 1.00, and 25 out of 28 estimates are significantly different from zero.

   Dental dimensions are highly heritable in captive brown‐mantled tamarins and free‐ranging rhesus macaques. The range of heritability estimates in these populations is broadly similar to those of baboons and humans. Evolvability tends to increase with heritability, although evolvability is high relative to heritability in some dimensions. Estimating evolvability helps to contextualizemore »differences in heritability, and the observed relationship between evolvability and heritability in dental dimensions requires further investigation.

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