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Abstract The geometry and motility of the stomach play a critical role in the digestion of ingested liquid meals. Sleeve gastrectomy, a common type of bariatric surgery used to reduce the size of the stomach, significantly alters the stomach's anatomy and motility, which impacts gastric emptying and digestion. In this study, we use an imaging data-based computational model, StomachSim, to investigate the consequences of sleeve gastrectomy. The pre-operative stomach anatomy was derived from imaging data, and the postsleeve gastrectomy shapes were generated for different resection volumes. We investigate the effect of sleeve sizes and motility patterns on gastric mixing and emptying. Simulations were conducted using an immersed-boundary flow solver, modeling a liquid meal to analyze changes in gastric mixing and emptying rates. The results reveal that different degrees of volume reduction and impaired gastric motility have complex effects on stomach's mixing and emptying functions, which are important factors in gastric health of the patient. Specifically, the total gastric liquid emptying rates increased by 21% with a 30% volume reduction and by 51% with reductions exceeding 50%, due to altered intragastric pressure. Additionally, impaired motility functions resulted in slower mixing, leading to delayed food emptying. These findings provide insights into the biomechanical effects of sleeve gastrectomy on gastric digestion and emptying functions, highlighting the potential of computational models to inform surgical planning and postoperative management.
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Effect of stomach motility on food hydrolysis and gastric emptying: Insight from computational models
The peristaltic motion of stomach walls combines with the secretion of digestive enzymes to initiate the process that breaks down food. In this study, the mixing, breakdown, and emptying of a liquid meal containing protein is simulated in a model of a human stomach. In this model, pepsin, the gastric enzyme responsible for protein hydrolysis, is secreted from the proximal region of the stomach walls and allowed to react with the contents of the stomach. The velocities of the retropulsive jet induced by the peristaltic motion, the emptying rate, and the extent of hydrolysis are quantified for a control case as well as for three other cases with reduced motility of the stomach, which may result from conditions such as diabetes mellitus. This study quantifies the effect of stomach motility on the rate of food breakdown and its emptying into the duodenum and we correlate these observations with the mixing in the stomach induced by the wall motion.
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- Award ID(s):
- 2019405
- PAR ID:
- 10417275
- Date Published:
- Journal Name:
- Physics of Fluids
- Volume:
- 34
- Issue:
- 11
- ISSN:
- 1070-6631
- Page Range / eLocation ID:
- 111909
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.1063/5.0120933
