Spatio-temporal activity patterns have been observed in a variety of brain areas in spontaneous activity, prior to or during action, or in response to stimuli. Biological mechanisms endowing neurons with the ability to distinguish between different sequences remain largely unknown. Learning sequences of spikes raises multiple challenges, such as maintaining in memory spike history and discriminating partially overlapping sequences. Here, we show that anti-Hebbian spike-timing dependent plasticity (STDP), as observed at cortico-striatal synapses, can naturally lead to learning spike sequences. We design a spiking model of the striatal output neuron receiving spike patterns defined as sequential input from a fixed set of cortical neurons. We use a simple synaptic plasticity rule that combines anti-Hebbian STDP and non-associative potentiation for a subset of the presented patterns called rewarded patterns. We study the ability of striatal output neurons to discriminate rewarded from non-rewarded patterns by firing only after the presentation of a rewarded pattern. In particular, we show that two biological properties of striatal networks, spiking latency and collateral inhibition, contribute to an increase in accuracy, by allowing a better discrimination of partially overlapping sequences. These results suggest that anti-Hebbian STDP may serve as a biological substrate for learning sequences of spikes.
Spike timing-dependent plasticity alters electrosensory neuron synaptic strength in vitro but does not consistently predict changes in sensory tuning in vivo
How do sensory systems optimize detection of behaviorally relevant stimuli when the sensory environment is constantly changing? We addressed the role of spike timing-dependent plasticity (STDP) in driving changes in synaptic strength in a sensory pathway and whether those changes in synaptic strength could alter sensory tuning. It is challenging to precisely control temporal patterns of synaptic activity in vivo and replicate those patterns in vitro in behaviorally relevant ways. This makes it difficult to make connections between STDP-induced changes in synaptic physiology and plasticity in sensory systems. Using the mormyrid species Brevimyrus niger and Brienomyrus brachyistius, which produce electric organ discharges for electrolocation and communication, we can precisely control the timing of synaptic input in vivo and replicate these same temporal patterns of synaptic input in vitro. In central electrosensory neurons in the electric communication pathway, using whole cell intracellular recordings in vitro, we paired presynaptic input with postsynaptic spiking at different delays. Using whole cell intracellular recordings in awake, behaving fish, we paired sensory stimulation with postsynaptic spiking using the same delays. We found that Hebbian STDP predictably alters sensory tuning in vitro and is mediated by NMDA receptors. However, the change in synaptic responses induced by sensory stimulation in vivo did not adhere to the direction predicted by the STDP observed in vitro. Further analysis suggests that this difference is influenced by polysynaptic activity, including inhibitory interneurons. Our findings suggest that STDP rules operating at identified synapses may not drive predictable changes in sensory responses at the circuit level. NEW & NOTEWORTHY We replicated behaviorally relevant temporal patterns of synaptic activity in vitro and used the same patterns during sensory stimulation in vivo. There was a Hebbian spike timing-dependent plasticity (STDP) pattern in vitro, but sensory responses in vivo did not shift according to STDP predictions. Analysis suggests that this disparity is influenced by differences in polysynaptic activity, including inhibitory interneurons. These results suggest that STDP rules at synapses in vitro do not necessarily apply to circuits in vivo.
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- Award ID(s):
- 1755071
- PAR ID:
- 10420479
- Date Published:
- Journal Name:
- Journal of Neurophysiology
- Volume:
- 129
- Issue:
- 5
- ISSN:
- 0022-3077
- Page Range / eLocation ID:
- 1127 to 1144
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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Abstract -
Synapses change on multiple timescales, ranging from milliseconds to minutes, due to a combination of both short- and long-term plasticity. Here we develop an extension of the common generalized linear model to infer both short- and long-term changes in the coupling between a pre- and postsynaptic neuron based on observed spiking activity. We model short-term synaptic plasticity using additive effects that depend on the presynaptic spike timing, and we model long-term changes in both synaptic weight and baseline firing rate using point process adaptive smoothing. Using simulations, we first show that this model can accurately recover time-varying synaptic weights (1) for both depressing and facilitating synapses, (2) with a variety of long-term changes (including realistic changes, such as due to STDP), (3) with a range of pre and postsynaptic firing rates, and (4) for both excitatory and inhibitory synapses. We then apply our model to two experimentally recorded putative synaptic connections. We find that simultaneously tracking fast changes in synaptic weights, slow changes in synaptic weights, and unexplained variations in baseline firing is essential. Omitting any one of these factors can lead to spurious inferences for the others. Altogether, this model provides a flexible framework for tracking short- and long-term variation in spike transmission.more » « less
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Spike-timing–dependent plasticity (STDP) is considered as a primary mechanism underlying formation of new memories during learning. Despite the growing interest in activity-dependent plasticity, it is still unclear whether synaptic plasticity rules inferred from in vitro experiments are correct in physiological conditions. The abnormally high calcium concentration used in in vitro studies of STDP suggests that in vivo plasticity rules may differ significantly from in vitro experiments, especially since STDP depends strongly on calcium for induction. We therefore studied here the influence of extracellular calcium on synaptic plasticity. Using a combination of experimental (patch-clamp recording and Ca2+imaging at CA3-CA1 synapses) and theoretical approaches, we show here that the classic STDP rule in which pairs of single pre- and postsynaptic action potentials induce synaptic modifications is not valid in the physiological Ca2+range. Rather, we found that these pairs of single stimuli are unable to induce any synaptic modification in 1.3 and 1.5 mM calcium and lead to depression in 1.8 mM. Plasticity can only be recovered when bursts of postsynaptic spikes are used, or when neurons fire at sufficiently high frequency. In conclusion, the STDP rule is profoundly altered in physiological Ca2+, but specific activity regimes restore a classical STDP profile.
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The Artificial Intelligence (AI) disruption continues unabated, albeit at extreme compute requirements. Neuromorphic circuits and systems offer a panacea for this extravagance. To this effect, event-based learning such as spike-timing-dependent plasticity (STDP) in spiking neural networks (SNNs) is an active area of research. Hebbian learning in SNNs fundamentally involves synaptic weight updates based on temporal correlations between pre- and post- synaptic neural activities. While there are broadly two approaches of realizing STDP, i.e. All-to-All versus Nearest Neighbor (NN), there exist strong arguments favoring the NN approach on the biologically plausibility front. In this paper, we present a novel current-mode implementation of a postsynaptic event-based NN STDP-based synapse. We leverage transistor subthreshold dynamics to generate exponential STDP traces using repurposed log-domain low-pass filter circuits. Synaptic weight operations involving addition and multiplications are achieved by the Kirchoff current law and the translinear principle respectively. Simulation results from the NCSU TSMC 180 nm technology are presented. Finally, the ideas presented here hold implications for engineering efficient hardware to meet the growing AI training and inference demands.more » « less
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The Artificial Intelligence (AI) disruption continues unabated, albeit at extreme compute requirements. Neuromorphic circuits and systems offer a panacea for this extravagance. To this effect, event-based learning such as spike-timing-dependent plasticity (STDP) in spiking neural networks (SNNs) is an active area of research. Hebbian learning in SNNs fundamentally involves synaptic weight updates based on temporal correlations between pre- and post- synaptic neural activities. While there are broadly two approaches of realizing STDP, i.e. All-to-All versus Nearest Neighbor (NN), there exist strong arguments favoring the NN approach on the biologically plausibility front. In this paper, we present a novel current-mode implementation of a postsynaptic event-based NN STDP-based synapse. We leverage transistor subthreshold dynamics to generate exponential STDP traces using repurposed log-domain low-pass filter circuits. Synaptic weight operations involving addition and multiplications are achieved by the Kirchoff current law and the translinear principle respectively. Simulation results from the NCSU TSMC 180 nm technology are presented. Finally, the ideas presented here hold implications for engineering efficient hardware to meet the growing AI training and inference demands.more » « less
- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.1152/jn.00498.2022
