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Summary Panel count data arise when the number of recurrent events experienced by each subject is observed intermittently at discrete examination times. The examination time process can be informative about the underlying recurrent event process even after conditioning on covariates. We consider a semiparametric accelerated mean model for the recurrent event process and allow the two processes to be correlated through a shared frailty. The regression parameters have a simple marginal interpretation of modifying the time scale of the cumulative mean function of the event process. A novel estimation procedure for the regression parameters and the baseline rate function is proposed based on a conditioning technique. In contrast to existing methods, the proposed method is robust in the sense that it requires neither the strong Poisson-type assumption for the underlying recurrent event process nor a parametric assumption on the distribution of the unobserved frailty. Moreover, the distribution of the examination time process is left unspecified, allowing for arbitrary dependence between the two processes. Asymptotic consistency of the estimator is established, and the variance of the estimator is estimated by a model-based smoothed bootstrap procedure. Numerical studies demonstrated that the proposed point estimator and variance estimator perform well with practical sample sizes. The methods are applied to data from a skin cancer chemoprevention trial.
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Statistical inference with semiparametric nonignorable nonresponse models
Abstract How to deal with nonignorable response is often a challenging problem encountered in statistical analysis with missing data. Parametric model assumption for the response mechanism is sensitive to model misspecification. We consider a semiparametric response model that relaxes the parametric model assumption in the response mechanism. Two types of efficient estimators, profile maximum likelihood estimator and profile calibration estimator, are proposed, and their asymptotic properties are investigated. Two extensive simulation studies are used to compare with some existing methods. We present an application of our method using data from the Korean Labor and Income Panel Survey.
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- Award ID(s):
- 1931380
- PAR ID:
- 10420822
- Publisher / Repository:
- Wiley-Blackwell
- Date Published:
- Journal Name:
- Scandinavian Journal of Statistics
- Volume:
- 50
- Issue:
- 4
- ISSN:
- 0303-6898
- Format(s):
- Medium: X Size: p. 1795-1817
- Size(s):
- p. 1795-1817
- Sponsoring Org:
- National Science Foundation
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