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Despite extensive efforts to identify interhemispheric functional connectivity (FC) with resting-state (rs-) fMRI, correlated low-frequency rs-fMRI signal fluctuation across homotopic cortices originates from multiple sources. It remains challenging to differentiate circuit-specific FC from global regulation. Here, we developed a bilateral line-scanning fMRI method to detect laminar-specific rs-fMRI signals from homologous forepaw somatosensory cortices with high spatial and temporal resolution in rat brains. Based on spectral coherence analysis, two distinct bilateral fluctuation spectral features were identified: ultra-slow fluctuation (<0.04 Hz) across all cortical laminae versus Layer (L) 2/3-specific evoked BOLD at 0.05 Hz based on 4 s on/16 s off block design and resting-state fluctuations at 0.08–0.1 Hz. Based on the measurements of evoked BOLD signal at corpus callosum (CC), this L2/3-specific 0.05 Hz signal is likely associated with neuronal circuit-specific activity driven by the callosal projection, which dampened ultra-slow oscillation less than 0.04 Hz. Also, the rs-fMRI power variability clustering analysis showed that the appearance of L2/3-specific 0.08–0.1 Hz signal fluctuation is independent of the ultra-slow oscillation across different trials. Thus, distinct laminar-specific bilateral FC patterns at different frequency ranges can be identified by the bilateral line-scanning fMRI method.
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Model-based stationarity filtering of long-term memory data applied to resting-state blood-oxygen-level-dependent signal
Resting-state blood-oxygen-level-dependent (BOLD) signal acquired through functional magnetic resonance imaging is a proxy of neural activity and a key mechanism for assessing neurological conditions. Therefore, practical tools to filter out artefacts that can compromise the assessment are required. On the one hand, a variety of tailored methods to preprocess the data to deal with identified sources of noise (e.g., head motion, heart beating, and breathing, just to mention a few) are in place. But, on the other hand, there might be unknown sources of unstructured noise present in the data. Therefore, to mitigate the effects of such unstructured noises, we propose a model-based filter that explores the statistical properties of the underlying signal (i.e., long-term memory). Specifically, we consider autoregressive fractional integrative process filters. Remarkably, we provide evidence that such processes can model the signals at different regions of interest to attain stationarity. Furthermore, we use a principled analysis where a ground-truth signal with statistical properties similar to the BOLD signal under the injection of noise is retrieved using the proposed filters. Next, we considered preprocessed (i.e., the identified sources of noise removed) resting-state BOLD data of 98 subjects from the Human Connectome Project. Our results demonstrate that the proposed filters decrease the power in the higher frequencies. However, unlike the low-pass filters, the proposed filters do not remove all high-frequency information, instead they preserve process-related higher frequency information. Additionally, we considered four different metrics (power spectrum, functional connectivity using the Pearson’s correlation, coherence, and eigenbrains) to infer the impact of such filter. We provided evidence that whereas the first three keep most of the features of interest from a neuroscience perspective unchanged, the latter exhibits some variations that could be due to the sporadic activity filtered out.
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- Award ID(s):
- 1936578
- PAR ID:
- 10426009
- Editor(s):
- Giove, Federico
- Date Published:
- Journal Name:
- PLOS ONE
- Volume:
- 17
- Issue:
- 7
- ISSN:
- 1932-6203
- Page Range / eLocation ID:
- e0268752
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
-
Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.1371/journal.pone.0268752
