Better understanding of the dose-toxicity relationship is critical for safe dose escalation to improve local control in late-stage cervical cancer radiotherapy. In this study, we introduced a convolutional neural network (CNN) model to analyze rectum dose distribution and predict rectum toxicity. Forty-two cervical cancer patients treated with combined external beam radiotherapy (EBRT) and brachytherapy (BT) were retrospectively collected, including twelve toxicity patients and thirty non-toxicity patients. We adopted a transfer learning strategy to overcome the limited patient data issue. A 16-layers CNN developed by the visual geometry group (VGG-16) of the University of Oxford was pre-trained on a large-scale natural image database, ImageNet, and fine-tuned with patient rectum surface dose maps (RSDMs), which were accumulated EBRT + BT doses on the unfolded rectum surface. We used the adaptive synthetic sampling approach and the data augmentation method to address the two challenges, data imbalance and data scarcity. The gradient-weighted class activation maps (Grad-CAM) were also generated to highlight the discriminative regions on the RSDM along with the prediction model. We compare different CNN coefficients fine-tuning strategies, and compare the predictive performance using the traditional dose volume parameters, e.g. D 0.1/1/2cc, and the texture features extracted from the RSDM. Satisfactory prediction performance was achieved with the proposed scheme, and we found that the mean Grad-CAM over the toxicity patient group has geometric consistence of distribution with the statistical analysis result, which indicates possible rectum toxicity location. The evaluation results have demonstrated the feasibility of building a CNN-based rectum dose-toxicity prediction model with transfer learning for cervical cancer radiotherapy.
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Dynamic Augmentation Data Selection for Few-shot Text Classification
Data augmentation has been a popular method for fine-tuning pre-trained language models to increase model robustness and performance. With augmentation data coming from modifying gold train data (in-sample augmentation) or being harvested from general domain unlabeled data (out-of-sample augmentation), the quality of such data is the key to successful fine-tuning. In this paper, we propose a dynamic data selection method to select effective augmentation data from different augmentation sources according to the model’s learning stage, by identifying a set of augmentation samples that optimally facilitates the learning process of the most current model. The method firstly filters out augmentation samples with noisy pseudo labels through a curriculum learning strategy, then estimates the effectiveness of reserved augmentation data by its influence scores on the current model at every update, allowing the data selection process tightly tailored to model parameters. And the two-stage augmentation strategy considers in-sample augmentation and out-of-sample augmentation in different learning stages. Experiments with both kinds of augmentation data on a variety of sentence classification tasks show that our method outperforms strong baselines, proving the effectiveness of our method. Analysis confirms the dynamic nature of the data effectiveness and the importance of model learning stages in utilization of augmentation data.
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- NSF-PAR ID:
- 10430112
- Date Published:
- Journal Name:
- Findings of the Association for Computational Linguistics: EMNLP 2022
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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Accepted Manuscript1.0
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