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Skin-Interfaced Superhydrophobic Insensible Sweat Sensors for Evaluating Body Thermoregulation and Skin Barrier Functions
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This study explored the feasibility of using fish skin bandages as a therapeutic option for third-degree skin burns. Following the California wildfires, clinical observations of animals with third-degree skin burns demonstrated increased comfort levels and reduced pain when treated with tilapia fish skin. Despite the promises of this therapy, there are few studies explaining the healing mechanisms behind the application of tilapia fish skin. In this study, mice with third-degree burns were treated with either a hydrocolloid adhesive bandage (control) (n = 16) or fish skin (n = 16) 7 days post-burn. Mice were subjected to histologic, hematologic, molecular, and gross evaluation at days 7, 16, and 28 post-burn. The fish skin offered no benefit to overall wound closure compared to hydrocolloids. Additionally, we detected no difference between fish skin and control treatments in regard to hypermetabolism or hematologic values. However, the fish skin groups exhibited 2 times more vascularization and 2 times higher expression of antimicrobial defensin peptide in comparison to controls. Proteomic analysis of the fish skin revealed the presence of antimicrobial peptides. Collectively, these data suggest that fish skin can serve as an innovative and cost-effective therapeutic alternative for burn victims to facilitate vascularization and reduce bacterial infection.more » « less
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This study explored the feasibility of using fish skin bandages as a therapeutic option for third-degree skin burns. Following the California wildfires, clinical observations of animals with third-degree skin burns demonstrated increased comfort levels and reduced pain when treated with tilapia fish skin. Proteomic analysis of the fish skin revealed the presence of antimicrobial peptides. In combination with histological and other data, these results suggest that fish skin can serve as an innovative and cost-effective therapeutic alternative for burn victims to facilitate vascularization and reduce bacterial infection.more » « less
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To investigate the well-observed racial disparities in computer vision systems that analyze images of humans, researchers have turned to skin tone as a more objective annotation than race metadata for fairness performance evaluations. However, the current state of skin tone annotation procedures is highly varied. For instance, researchers use a range of untested scales and skin tone categories, have unclear annotation procedures, and provide inadequate analyses of uncertainty. In addition, little attention is paid to the positionality of the humans involved in the annotation process—both designers and annotators alike—and the historical and sociological context of skin tone in the United States. Our work is the first to investigate the skin tone annotation process as a sociotechnical project. We surveyed recent skin tone annotation procedures and conducted annotation experiments to examine how subjective understandings of skin tone are embedded in skin tone annotation procedures. Our systematic literature review revealed the uninterrogated association between skin tone and race and the limited effort to analyze annotator uncertainty in current procedures for skin tone annotation in computer vision evaluation. Our experiments demonstrated that design decisions in the annotation procedure such as the order in which the skin tone scale is presented or additional context in the image (i.e., presence of a face) significantly affected the resulting inter-annotator agreement and individual uncertainty of skin tone annotations. We call for greater reflexivity in the design, analysis, and documentation of procedures for evaluation using skin tone.more » « less
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.1021/acsnano.2c11267
