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Title: Zwitterionic Biomaterials
The term “zwitterionic polymers” refers to polymers that bear a pair of oppositely charged groups in their repeating units. When these oppositely charged groups are equally distributed at the molecular level, the molecules exhibit an overall neutral charge with a strong hydration effect via ionic solvation. The strong hydration effect constitutes the foundation of a series of exceptional properties of zwitterionic materials, including resistance to protein adsorption, lubrication at interfaces, promotion of protein stabilities, antifreezing in solutions, etc. As a result, zwitterionic materials have drawn great attention in biomedical and engineering applications in recent years. In this review, we give a comprehensive and panoramic overview of zwitterionic materials, covering the fundamentals of hydration and nonfouling behaviors, different types of zwitterionic surfaces and polymers, and their biomedical applications.  more » « less
Award ID(s):
2002940
NSF-PAR ID:
10437721
Author(s) / Creator(s):
Date Published:
Journal Name:
Chemical reviews
Volume:
122
Issue:
23
ISSN:
0009-2665
Page Range / eLocation ID:
17073–17154
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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