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Title: Ca 2+ release or Ca 2+ entry, that is the question: what governs Ca 2+ oscillations in pancreatic β cells?
The standard model for Ca 2+ oscillations in insulin-secreting pancreatic β cells centers on Ca 2+ entry through voltage-activated Ca 2+ channels. These work in combination with ATP-dependent K + channels, which are the bridge between the metabolic state of the cells and plasma membrane potential. This partnership underlies the ability of the β cells to secrete insulin appropriately on a minute-to-minute time scale to control whole body plasma glucose. Though this model, developed over more than 40 years through many cycles of experimentation and mathematical modeling, has been very successful, it has been challenged by a hypothesis that calcium-induced calcium release from the endoplasmic reticulum through ryanodine or inositol trisphosphate (IP3) receptors is instead the key driver of islet oscillations. We show here that the alternative model is in fact incompatible with a large body of established experimental data and that the new observations offered in support of it can be better explained by the standard model.  more » « less
Award ID(s):
1853342
PAR ID:
10443714
Author(s) / Creator(s):
; ; ; ; ;
Date Published:
Journal Name:
American Journal of Physiology-Endocrinology and Metabolism
Volume:
324
Issue:
6
ISSN:
0193-1849
Page Range / eLocation ID:
E477 to E487
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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