Sleep is ancient and genetically conserved across phylogeny. Neuropeptide signaling plays a fundamental role in the regulation of sleep for mammals, fish, and invertebrates like Caenorhabditis elegans. Developmentally timed-sleep and stress-induced sleep of C. elegans are controlled by distinct and overlapping neuropeptide pathways. The RPamide neuropeptides nlp-2, nlp-22, and nlp-23, play antagonistic roles during the regulation of developmentally-timed sleep, however, their role in stress-induced sleep has not been explored. These genes are linked on the X chromosome, which has made genetic analyses challenging. Here we used CRISPR to generate new alleles of nlp-22 and nlp-23, nlp-22;nlp-23 double mutants, and nlp-2;nlp-22;nlp-23 triple mutants. Confirming previous studies, we find that nlp-22 is required for developmentally-timed sleep, and show that nlp-23 is also required. However, all three genes are dispensable for stress-induced sleep.
more »
« less
What Do NLP Researchers Believe? Results of the NLP Community Metasurvey
- Award ID(s):
- 2046556
- PAR ID:
- 10445705
- Date Published:
- Journal Name:
- Proceedings of the 61st Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers)
- Page Range / eLocation ID:
- 16334 to 16368
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
More Like this
-
-
Human speakers have an extensive toolkit of ways to express themselves. In this paper, we engage with an idea largely absent from discussions of meaning in natural language understanding—namely, that the way something is expressed reflects different ways of conceptualizing or construing the information being conveyed. We first define this phenomenon more precisely, drawing on considerable prior work in theoretical cognitive semantics and psycholinguistics. We then survey some dimensions of construed meaning and show how insights from construal could inform theoretical and practical work in NLP.more » « less
An official website of the United States government

