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Title: The McdAB system positions α‐carboxysomes in proteobacteria
Abstract Plain language summary

Cyanobacteria are well known to fix atmospheric CO2into sugars using the enzyme Rubisco. Less appreciated are the carbon‐fixing abilities of proteobacteria with diverse metabolisms. Bacterial Rubisco is housed within organelles called carboxysomes that increase enzymatic efficiency. Here we show that proteobacterial carboxysomes are distributed in the cell by two proteins, McdA and McdB. McdA on the nucleoid interacts with McdB on carboxysomes to equidistantly space carboxysomes from one another, ensuring metabolic homeostasis and a proper inheritance of carboxysomes following cell division. This study illuminates how widespread carboxysome positioning systems are among diverse bacteria. Carboxysomes significantly contribute to global carbon fixation; therefore, understanding the spatial organization mechanism shared across the bacterial world is of great interest.

 
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Award ID(s):
1817478 1941966
NSF-PAR ID:
10449836
Author(s) / Creator(s):
 ;  ;  ;  ;  
Publisher / Repository:
Wiley-Blackwell
Date Published:
Journal Name:
Molecular Microbiology
Volume:
116
Issue:
1
ISSN:
0950-382X
Page Range / eLocation ID:
p. 277-297
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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