In plants,
A microbe’s ecological niche and biotechnological utility are determined by its specific set of co‐evolved metabolic pathways. The acquisition of new pathways, through horizontal gene transfer or genetic engineering, can have unpredictable consequences. Here we show that two different pathways for coumarate catabolism failed to function when initially transferred into
- NSF-PAR ID:
- 10459807
- Publisher / Repository:
- Wiley-Blackwell
- Date Published:
- Journal Name:
- Molecular Microbiology
- Volume:
- 112
- Issue:
- 6
- ISSN:
- 0950-382X
- Page Range / eLocation ID:
- p. 1784-1797
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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Abstract Background Mutations in leucine-rich repeat kinase 2 (
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Conclusions This work supports a protective role of LRRK2 kinase inhibition in G2019S carriers and provides a rational workflow for systematic evaluation of brain-wide phenotypes in therapeutic development.
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