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Title: Diversity and distribution of the bmp gene cluster and its Polybrominated products in the genus Pseudoalteromonas
Summary

The production of pentabromopseudilin and related brominated compounds byPseudoalteromonasspp. has recently been linked to thebmpbiosynthetic gene cluster. This study explored the distribution and evolutionary history of this gene cluster in the genusPseudoalteromonas. A phylogeny of the genus revealed numerous clades that do not contain type strains, suggesting considerable species level diversity has yet to be described. Comparative genomics revealed four distinct versions of the gene cluster distributed among 19 of the 101Pseudoalteromonasgenomes examined. These were largely localized to the least inclusive clades containing thePseudoalteromonas luteoviolaceaandPseudoalteromonas phenolicatype strains and show clear evidence of gene and gene cluster loss in certain lineages.Bmpgene phylogeny is largely congruent with thePseudoalteromonasspecies phylogeny, suggesting vertical inheritance within the genus. However, the gene cluster is found in three different genomic environments suggesting either chromosomal rearrangement or multiple acquisition events.Bmpconservation within certain lineages suggests the encoded products are highly relevant to the ecology of these bacteria.

 
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NSF-PAR ID:
10461130
Author(s) / Creator(s):
 ;  ;  ;  ;  ;  ;  ;  
Publisher / Repository:
Wiley-Blackwell
Date Published:
Journal Name:
Environmental Microbiology
Volume:
21
Issue:
5
ISSN:
1462-2912
Page Range / eLocation ID:
p. 1575-1585
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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