In many cell types, mitochondria undergo extensive fusion and fission to form dynamic, responsive network structures that contribute to a number of homeostatic, metabolic, and signaling functions. The relationship between the dynamic interactions of individual mitochondrial units and the cell-scale network architecture remains an open area of study. In this work, we use coarse-grained simulations and approximate analytic models to establish how the network morphology is governed by local mechanical and kinetic parameters. The transition between fragmented structures and extensive networks is controlled by local fusion-to-fission ratios, network density, and geometric constraints. Similar fusion rate constants are found to account for the very different structures formed by mammalian networks (poised at the percolation transition) and well-connected budding yeast networks. Over a broad parameter range, the simulated network structures can be described by effective mean-field association constants that exhibit a nonlinear dependence on the microscopic nonequilibrium fusion, fission, and transport rates. Intermediate fusion rate constants are shown to result in the highest rates of network remodeling, with mammalian mitochondrial networks situated in a regime of high turnover. This spatially resolved modeling and simulation framework helps elucidate the emergence of cellular scale network structures, and allows for the quantitative extraction of microscopic kinetic parameters from past and future experimental data. Published by the American Physical Society2024
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Energy competition and pairing effect for the fission path with a microscopic model
We studied the fission barrier of 236 U with a microscopic mean-field model employing Skyrme-type effective interaction. It has been known that the microscopic mean-field calculation had a trend of overestimating the fission barriers derived from the fission cross section, and our results were found to be in accord with it. To reveal a major factor of the discrepancy, we investigated various components of the Skyrme energy-density functional building of the fission barrier height by a static mean-field model, including nuclear pairing correlation. We found that the spin-orbit and pairing terms affected the fine structure of the fission barrier as a function of elongation of the nucleus. Therefore, we investigated the sensitivity of the fission barrier height on the pairing strength, considering the change of level density along the calculated fission path.
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- Award ID(s):
- 1927130
- PAR ID:
- 10464899
- Date Published:
- Journal Name:
- Frontiers in Physics
- Volume:
- 10
- ISSN:
- 2296-424X
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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