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Title: A Modified Neighborhood Hypothesis Test for Population Mean in Functional Data
When dealing with very high-dimensional and functional data, rank deficiency of sample covariance matrix often complicates the tests for population mean. To alleviate this rank deficiency problem, Munk et al. (J Multivar Anal 99:815–833, 2008) proposed neighborhood hypothesis testing procedure that tests whether the population mean is within a small, pre-specified neighborhood of a known quantity, M. How could we objectively specify a reasonable neighborhood, particularly when the sample space is unbounded? What should be the size of the neighborhood? In this article, we develop the modified neighborhood hypothesis testing framework to answer these two questions.We define the neighborhood as a proportion of the total amount of variation present in the population of functions under study and proceed to derive the asymptotic null distribution of the appropriate test statistic. Power analyses suggest that our approach is appropriate when sample space is unbounded and is robust against error structures with nonzero mean. We then apply this framework to assess whether the near-default sigmoidal specification of dose-response curves is adequate for widely used CCLE database. Results suggest that our methodology could be used as a pre-processing step before using conventional efficacy metrics, obtained from sigmoid models (for example: IC50 or AUC), as downstream predictive targets.  more » « less
Award ID(s):
2007418
PAR ID:
10467518
Author(s) / Creator(s):
; ; ;
Editor(s):
Mateu, Jorge
Publisher / Repository:
Springer, International Biometric Society
Date Published:
Journal Name:
Journal of Agricultural, Biological and Environmental Statistics
ISSN:
1085-7117
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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