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Title: Adaptation to Overflow Metabolism by Mutations That Impair tRNA Modification in Experimentally Evolved Bacteria
There is growing evidence that the fundamental components of protein translation can play multiple roles in maintaining cellular homeostasis. Enzymes that interact with transfer RNAs not only ensure faithful decoding of the genetic code but also help signal the metabolic state by reacting to imbalances in essential building blocks like free amino acids and cofactors.  more » « less
Award ID(s):
1818131
PAR ID:
10481561
Author(s) / Creator(s):
; ; ; ; ;
Editor(s):
Babitzke, Paul
Publisher / Repository:
ASM Journals
Date Published:
Journal Name:
mBio
Volume:
14
Issue:
2
ISSN:
2150-7511
Subject(s) / Keyword(s):
experimental evolution tRNA modification tradeoff translational control
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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