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Bacterial infections pose a serious public health concern, especially when an infectious disease has a multidrug resistant causative agent. Such multidrug resistant bacteria can compromise the clinical utility of major chemotherapeutic antimicrobial agents. Drug and multidrug resistant bacteria harbor several distinct molecular mechanisms for resistance. Bacterial antimicrobial agent efflux pumps represent a major mechanism of clinical resistance. The major facilitator superfamily (MFS) is one of the largest groups of solute transporters to date and includes a significant number of bacterial drug and multidrug efflux pumps. We review recent work on the modulation of multidrug efflux pumps, paying special attention to those transporters belonging primarily to the MFS.
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Isolating the effects of gate layer permeability and sorbent density on the performance of solute-selective polymeric ion pumps
The design of polymeric ion pumps that isolate target solutes from complex milieus is examined. The analysis shows that current materials possess the properties needed to fabricate polymeric ions pumps that outperform conventional membrane systems.
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- Award ID(s):
- 2147605
- PAR ID:
- 10481591
- Publisher / Repository:
- Royal Society of Chemsitry
- Date Published:
- Journal Name:
- Molecular Systems Design & Engineering
- Volume:
- 8
- Issue:
- 11
- ISSN:
- 2058-9689
- Page Range / eLocation ID:
- 1418 to 1429
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.1039/D3ME00073G
