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Abstract Three-dimensional (3D) bio-printing is a rapidly growing field attempting to recreate functional tissues for medical and pharmaceutical purposes. The printability of multiple materials encapsulating various living cells can take this emerging effort closer to tissue regeneration. In our earlier research, we designed a Y-like nozzle connector system capable of switching materials between more than one filament with continuous deposition. The device had a fixed switching angle, was made from plastic, and was suitable for one-time use. This paper presents the extension of our previously proposed nozzle system. We considered 30°, 45°, 60°, and 90° angles (vertical and tilted) between the two materials and chose stainless steel as a material to fabricate those nozzle connectors. The overall material switching time was recorded and compared to analyze the effects of those various angles. Our previously developed hybrid hydrogel (4% Alginate and 4% Carboxymethyl Cellulose, CMC) was used as a test material to flow through the nozzle system. These in-house fabricated nozzle connectors are reusable, easy to clean, and sterile, allowing smooth material transition and flow.
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Tuning Process Parameters for Multi-Material Extrusion Through In-house Nozzle System for 3D Bio-printing Process
The emerging field of three-dimensional bio-printing seeks to recreate functional tissues for medical and pharmaceutical purposes. With the ability to print diverse materials containing different living cells, this growing area may bring us closer to achieving tissue regeneration. In previous research, we developed a Y-shaped nozzle connection device that facilitated the continuous deposition of materials across multiple filaments. This plastic device had a fixed switching angle and was intended for single use. In this study, we present an extension of our previous nozzle system. To fabricate the nozzle connectors, we chose stainless steel and considered angles of 300, 450, and 900 (both vertical and tilted) between the two materials. The total material switching time was recorded and compared to analyze the effects of these angles. We used our previously developed hybrid hydrogel (4% Alginate and 4% Carboxymethyl Cellulose, CMC) as a test material to flow through the nozzle system. These in-house fabricated nozzle connectors are reusable, and sterile and enable smooth material transition and flow.
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- Award ID(s):
- 1757371
- PAR ID:
- 10486630
- Editor(s):
- Eds: Babski-Reeves, K; Eksioglu, B; Hampton, D.
- Publisher / Repository:
- Institute of Industrial and Systems Engineers
- Date Published:
- Journal Name:
- Proceedings of the IISE Annual Conference & Expo 2023
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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