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How does growth encode form in developing organisms? Many different spatiotemporal growth profiles may sculpt tissues into the same target 3D shapes, but only specific growth patterns are observed in animal and plant development. In particular, growth profiles may differ in their degree of spatial variation and growth anisotropy; however, the criteria that distinguish observed patterns of growth from other possible alternatives are not understood. Here we exploit the mathematical formalism of quasiconformal transformations to formulate the problem of “growth pattern selection” quantitatively in the context of 3D shape formation by growing 2D epithelial sheets. We propose that nature settles on growth patterns that are the “simplest” in a certain way. Specifically, we demonstrate that growth pattern selection can be formulated as an optimization problem and solved for the trajectories that minimize spatiotemporal variation in areal growth rates and deformation anisotropy. The result is a complete prediction for the growth of the surface, including not only a set of intermediate shapes, but also a prediction for cell displacement along those surfaces in the process of growth. Optimization of growth trajectories for both idealized surfaces and those observed in nature show that relative growth rates can be uniformized at the cost of introducing anisotropy. Minimizing the variation of programmed growth rates can therefore be viewed as a generic mechanism for growth pattern selection and may help us to understand the prevalence of anisotropy in developmental programs. Published by the American Physical Society2025
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Growing patterns
Abstract Pattern forming systems allow for a wealth of states, where wavelengths and orientation of patterns varies and defects disrupt patches of monocrystalline regions. Growth of patterns has long been recognized as a strong selection mechanism. We present here recent and new results on the selection of patterns in situations where the pattern-forming region expands in time. The wealth of phenomena is roughly organised in bifurcation diagrams that depict wavenumbers of selected crystalline states as functions of growth rates. We show how a broad set of mathematical and numerical tools can help shed light into the complexity of this selection process.
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- PAR ID:
- 10498411
- Publisher / Repository:
- IOP
- Date Published:
- Journal Name:
- Nonlinearity
- Volume:
- 36
- Issue:
- 10
- ISSN:
- 0951-7715
- Page Range / eLocation ID:
- R1 to R51
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.1088/1361-6544/acf265
