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Title: White matter hyperintensity longitudinal morphometric analysis in association with Alzheimer disease
Abstract INTRODUCTIONVascular damage in Alzheimer's disease (AD) has shown conflicting findings particularly when analyzing longitudinal data. We introduce white matter hyperintensity (WMH) longitudinal morphometric analysis (WLMA) that quantifies WMH expansion as the distance from lesion voxels to a region of interest boundary. METHODSWMH segmentation maps were derived from 270 longitudinal fluid‐attenuated inversion recovery (FLAIR) ADNI images. WLMA was performed on five data‐driven WMH patterns with distinct spatial distributions. Amyloid accumulation was evaluated with WMH expansion across the five WMH patterns. RESULTSThe preclinical group had significantly greater expansion in the posterior ventricular WM compared to controls. Amyloid significantly associated with frontal WMH expansion primarily within AD individuals. WLMA outperformed WMH volume changes for classifying AD from controls primarily in periventricular and posterior WMH. DISCUSSIONThese data support the concept that localized WMH expansion continues to proliferate with amyloid accumulation throughout the entirety of the disease in distinct spatial locations.  more » « less
Award ID(s):
2054199
PAR ID:
10499566
Author(s) / Creator(s):
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
Corporate Creator(s):
Publisher / Repository:
Alzhemier's Association
Date Published:
Journal Name:
Alzheimer's & Dementia
Volume:
19
Issue:
10
ISSN:
1552-5260
Page Range / eLocation ID:
4488 to 4497
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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