skip to main content


Search for: All records

Award ID contains: 2054199

Note: When clicking on a Digital Object Identifier (DOI) number, you will be taken to an external site maintained by the publisher. Some full text articles may not yet be available without a charge during the embargo (administrative interval).
What is a DOI Number?

Some links on this page may take you to non-federal websites. Their policies may differ from this site.

  1. Abstract INTRODUCTION

    Vascular damage in Alzheimer's disease (AD) has shown conflicting findings particularly when analyzing longitudinal data. We introduce white matter hyperintensity (WMH) longitudinal morphometric analysis (WLMA) that quantifies WMH expansion as the distance from lesion voxels to a region of interest boundary.

    METHODS

    WMH segmentation maps were derived from 270 longitudinal fluid‐attenuated inversion recovery (FLAIR) ADNI images. WLMA was performed on five data‐driven WMH patterns with distinct spatial distributions. Amyloid accumulation was evaluated with WMH expansion across the five WMH patterns.

    RESULTS

    The preclinical group had significantly greater expansion in the posterior ventricular WM compared to controls. Amyloid significantly associated with frontal WMH expansion primarily within AD individuals. WLMA outperformed WMH volume changes for classifying AD from controls primarily in periventricular and posterior WMH.

    DISCUSSION

    These data support the concept that localized WMH expansion continues to proliferate with amyloid accumulation throughout the entirety of the disease in distinct spatial locations.

     
    more » « less
    Free, publicly-accessible full text available October 1, 2024
  2. Abstract

    We establish a theory of noncommutative (NC) functions on a class of von Neumann algebras with a particular direct sum property, e.g.,$B({\mathcal H})$. In contrast to the theory’s origins, we do not rely on appealing to results from the matricial case. We prove that the$k{\mathrm {th}}$directional derivative of any NC function at a scalar point is ak-linear homogeneous polynomial in its directions. Consequences include the fact that NC functions defined on domains containing scalar points can be uniformly approximated by free polynomials as well as realization formulas for NC functions bounded on particular sets, e.g., the NC polydisk and NC row ball.

     
    more » « less
    Free, publicly-accessible full text available June 1, 2024
  3. Free, publicly-accessible full text available November 1, 2024
  4. Free, publicly-accessible full text available September 1, 2024
  5. Free, publicly-accessible full text available June 1, 2024
  6. Jury and Martin establish an analogue of the classical inner-outer factorization of Hardy space functions. They show that every functionffin a Hilbert function space with a normalized complete Pick reproducing kernel has a factorization of the typef=φ<#comment/>gf=\varphi g, whereggis cyclic,φ<#comment/>\varphiis a contractive multiplier, and‖<#comment/>f‖<#comment/>=‖<#comment/>g‖<#comment/>\|f\|=\|g\|. In this paper we show that if the cyclic factor is assumed to be what we call free outer, then the factors are essentially unique, and we give a characterization of the factors that is intrinsic to the space. That lets us compute examples. We also provide several applications of this factorization.

     
    more » « less