skip to main content
US FlagAn official website of the United States government
dot gov icon
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
https lock icon
Secure .gov websites use HTTPS
A lock ( lock ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.


Title: Sensitivity volume as figure-of-merit for maximizing data importance in electrical impedance tomography
Abstract Objective.Electrical impedance tomography (EIT) is a noninvasive imaging method whereby electrical measurements on the periphery of a heterogeneous conductor are inverted to map its internal conductivity. The EIT method proposed here aims to improve computational speed and noise tolerance by introducing sensitivity volume as a figure-of-merit for comparing EIT measurement protocols.Approach.Each measurement is shown to correspond to a sensitivity vector in model space, such that the set of measurements, in turn, corresponds to a set of vectors that subtend a sensitivity volume in model space. A maximal sensitivity volume identifies the measurement protocol with the greatest sensitivity and greatest mutual orthogonality. A distinguishability criterion is generalized to quantify the increased noise tolerance of high sensitivity measurements.Main result.The sensitivity volume method allows the model space dimension to be minimized to match that of the data space, and the data importance to be increased within an expanded space of measurements defined by an increased number of contacts.Significance.The reduction in model space dimension is shown to increasecomputational efficiency, accelerating tomographic inversion by several orders of magnitude, while the enhanced sensitivitytolerates higher noiselevels up to several orders of magnitude larger than standard methods.  more » « less
Award ID(s):
1912694
PAR ID:
10500855
Author(s) / Creator(s):
; ; ; ; ; ;
Publisher / Repository:
IOP Publishing
Date Published:
Journal Name:
Physiological Measurement
Volume:
45
Issue:
4
ISSN:
0967-3334
Format(s):
Medium: X Size: Article No. 045004
Size(s):
Article No. 045004
Sponsoring Org:
National Science Foundation
More Like this
  1. Electrical Impedance Tomography (EIT) is a well-known imaging technique for detecting the electrical properties of an object in order to detect anomalies, such as conductive or resistive targets. More specifically, EIT has many applications in medical imaging for the detection and location of bodily tumors since it is an affordable and non-invasive method, which aims to recover the internal conductivity of a body using voltage measurements resulting from applying low frequency current at electrodes placed at its surface. Mathematically, the reconstruction of the internal conductivity is a severely ill-posed inverse problem and yields a poor quality image reconstruction. To remedy this difficulty, at least in part, we regularize and solve the nonlinear minimization problem by the aid of a Krylov subspace-type method for the linear sub problem during each iteration. In EIT, a tumor or general anomaly can be modeled as a piecewise constant perturbation of a smooth background, hence, we solve the regularized problem on a subspace of relatively small dimension by the Flexible Golub-Kahan process that provides solutions that have sparse representation. For comparison, we use a well-known modified Gauss–Newton algorithm as a benchmark. Using simulations, we demonstrate the effectiveness of the proposed method. The obtained reconstructions indicate that the Krylov subspace method is better adapted to solve the ill-posed EIT problem and results in higher resolution images and faster convergence compared to reconstructions using the modified Gauss–Newton algorithm. 
    more » « less
  2. Kim, Jaehwan (Ed.)
    Electrical impedance tomography (EIT) is a rising and emerging imaging technique with great potential in many areas, especially in functional brain imaging applications. An EIT system with high speed and accuracy can have many applications to medical devices supporting in diagnosis and treatment of neurological disorders and diseases. In this research, EIT algorithms and hardware are developed and improved to increase reconstructed images' accuracy and decrease the reconstruction time. Due to multiplexer design limitations, EIT measurements are subject to strong capacitive effects from charging and discharging in switching cycles around 300 to 400 samples per 1280 samples (in 10 milliseconds sampling). We developed an algorithm to choose data in steady-state condition only selectively. This method improves the signal-to-noise ratio and results in better reconstruction images. An algorithm to effectively synchronize the beginning points of data was developed to increase the system's speed. This presentation also presents the EIT system's hardware architecture based on Texas Instruments Fixed-Point Digital Signal Processor - TMS320VC5509A, which is low-cost, high potential in popularity the community in the future. For high operation speed, we propose the EIT system used Sitara™ AM57x processors of Texas Instruments. 
    more » « less
  3. null (Ed.)
    Abstract Phytoplankton biomass is routinely estimated using relationships between cell volume and carbon (C) and nitrogen (N) content that have been defined using diverse plankton that span orders of magnitude in size. Notably, volume has traditionally been estimated with geometric approximations of cell shape using cell dimensions from planar two-dimensional (2D) images, which requires assumptions about the third, depth dimension. Given advances in image processing, we examined how cell volumes determined from three-dimensional (3D), confocal images affected established relationships between phytoplankton cell volume and C and N content. Additionally, we determined that growth conditions could result in 30–40% variation in cellular N and C. 3D phytoplankton cell volume measurements were on average 15% greater than the geometric approximations from 2D images. Volume method variation was minimal compared to both intraspecific variation in volumes (~30%) and the 50-fold variation in elemental density among species. Consequently, C:vol and N:vol relationships were unaltered by volume measurement method and growth environment. Recent advances in instrumentation, including those for at sea and autonomous applications can be used to estimate plankton biomass directly. Going forward, we recommend instrumentation that permits species identification alongside size and shape characteristics for plankton biomass estimates. 
    more » « less
  4. Abstract We introduce COMAP-EoR, the next generation of the Carbon Monoxide Mapping Array Project aimed at extending CO intensity mapping to the Epoch of Reionization. COMAP-EoRsupplements the existing 30 GHz COMAP Pathfinder with two additional 30 GHz instruments and a new 16 GHz receiver. This combination of frequencies will be able to simultaneously map CO(1–0) and CO(2–1) at reionization redshifts (z∼ 5–8) in addition to providing a significant boost to thez∼ 3 sensitivity of the Pathfinder. We examine a set of existing models of the EoR CO signal, and find power spectra spanning several orders of magnitude, highlighting our extreme ignorance about this period of cosmic history and the value of the COMAP-EoRmeasurement. We carry out the most detailed forecast to date of an intensity mapping cross correlation, and find that five out of the six models we consider yield signal to noise ratios (S/Ns) ≳ 20 for COMAP-EoR, with the brightest reaching a S/N above 400. We show that, for these models, COMAP-EoRcan make a detailed measurement of the cosmic molecular gas history fromz∼ 2–8, as well as probe the population of faint, star-forming galaxies predicted by these models to be undetectable by traditional surveys. We show that, for the single model that does not predict numerous faint emitters, a COMAP-EoR-type measurement is required to rule out their existence. We briefly explore prospects for a third-generation Expanded Reionization Array (COMAP-ERA) capable of detecting the faintest models and characterizing the brightest signals in extreme detail. 
    more » « less
  5. Frequency combs have revolutionized the measurement of time and frequency and impacted a wide range of applications spanning basic physics, astrophysics, medicine, and defense. The key theoretical issues in understanding and designing frequency combs are finding regions in the adjustable parameter space where combs operate stably, determining their noise performance, and optimizing them for high power, low noise, and/or large bandwidth. Here, we present a unique set of computational tools that we have developed that allow us to efficiently address these issues. These tools combine 400-year-old dynamical systems theory with modern computational methods, and they are 3–5 orders of magnitude faster than standard evolutionary methods and provide important physical insight. We have applied these tools to frequency combs from passively modelocked lasers with fast and with slow saturable absorbers and to frequency combs from microresonators. Our methods predict improved operating regimes for combs that are produced from both the passively modelocked lasers and the microresonators. 
    more » « less