More Like this

1. Total Syntheses of (±)‐Dracocephalone A and (±)‐Dracocequinones A and B

   https://doi.org/10.1002/anie.202210821  

   Hwang, Taehwan; Tuccinardi, Joseph P.; Beard, Alexandra A.; Jackson, Amy C.; Jung, Min J.; Wood, John L. (October 2022, Angewandte Chemie International Edition)

   Abstract Described herein are the first total syntheses of (±)‐dracocephalone A (1) and (±)‐dracocequinones A (4) and B (5). The synthesis was initially envisioned as proceeding through an intramolecular isobenzofuran Diels–Alder reaction, a strategy that eventually evolved into a Lewis acid‐promoted spirocyclization. This highly diastereoselective transformation set the stage fortrans‐decalin formation and a late‐stage Suárez oxidation that produced a [3.2.1] oxabicycle suited for conversion to1. Brønsted acid‐mediated aromatization, followed by a series of carefully choreographed oxidations, allowed for rearrangement to a [2.2.2] oxabicycle poised for conversion to4and5. 

   more » « less
2. Folding points to a point and lines to a line

   Akitaya, Hugo A.; Ballinger, Brad; Demaine, Erik D.; Hull, Thomas C.; Schmidt, Christiane (August 2021, Proceedings of the 33rd Canadian Conference on Computational Geometry (CCCG 2021))

   He, Meng; Sheehy, Don (Ed.)

   We introduce basic, but heretofore generally unexplored, problems in computational origami that are similar in style to classic problems from discrete and computational geometry. We consider the problems of folding each corner of a polygon P to a point p and folding each edge of a polygon P onto a line segment L that connects two boundary points of P and compute the number of edges of the polygon containing p or L limited by crease lines and boundary edges. 

   more » « less
3. geomorph v4.0 and gmShiny: Enhanced analytics and a new graphical interface for a comprehensive morphometric experience

   https://doi.org/10.1111/2041-210X.13723  

   Baken, Erica K.; Collyer, Michael L.; Kaliontzopoulou, Antigoni; Adams, Dean C. (September 2021, Methods in Ecology and Evolution)

   Abstract Geometric morphometric (GM) tools are essential for meaningfully quantifying and understanding patterns of variation in complex traits like shape. In this field, the breadth of answerable questions has grown dramatically in recent years through the development of new analyses and increased computational efficiency.In this note, we describe the ways in whichgeomorph, a widely usedRpackage for quantifying and analysing GM data, has grown with the field.We presentgeomorph v4.0and describe the ways in which this version has dramatically improved upon previous versions. We also present a new graphical user interface for easy implementation,gmShiny.These contributions positiongeomorphto be the primary tool for GM analyses, particularly those employing a phylogenetic comparative approach. 

   more » « less
4. Computational sustainability: computing for a better world and a sustainable future

   https://doi.org/10.1145/3339399  

   Gomes, Carla; Dietterich, Thomas; Barrett, Christopher; Conrad, Jon; Dilkina, Bistra; Ermon, Stefano; Fang, Fei; Farnsworth, Andrew; Fern, Alan; Fern, Xiaoli; et al (August 2019, Communications of the ACM)

   Computer and information scientists join forces with other fields to help solve societal and environmental challenges facing humanity, in pursuit of a sustainable future. 

   more » « less
5. KMT-2024-BLG-0404L: A triple microlensing system consisting of a star, a brown dwarf, and a planet

   https://doi.org/10.1051/0004-6361/202452760  

   Han, Cheongho; Udalski, Andrzej; Lee, Chung-Uk; Ryu, Yoon-Hyun; Albrow, Michael D; Chung, Sun-Ju; Gould, Andrew; Hwang, Kyu-Ha; Kil_Jung, Youn; Shin, In-Gu; et al (August 2025, Astronomy & Astrophysics)

   Aims. We have investigated the lensing event KMT-2024-BLG-0404. The light curve of the event exhibited a complex structure with multiple distinct features, including two prominent caustic spikes, two cusp bumps, and a brief discontinuous feature between the caustic spikes. While a binary-lens model captured the general anomaly pattern, it could not account for a discontinuous anomaly feature between the two caustic spikes. Methods. To explore the origin of the unexplained feature, we conducted more advanced modeling beyond the standard binary-lens framework. This investigation demonstrated that the previously unexplained anomaly was resolved by introducing an additional lens component with planetary mass. Results. The estimated masses of the lens components areM_p= 17.3_−8.8^+25.5M_Efor the planet, andM_h,A= 0.090_−0.046^+0.133M_⊙andM_h,B= 0.026_−0.013^+0.038M_⊙for the binary host stars. Based on these mass estimates, the lens system is identified as a planetary system where a Uranus-mass planet orbits a binary consisting of a late M dwarf and a brown dwarf. The distance to the planetary system is estimated to beD_L= 7.21_−0.97^+0.93kpc, with an 82% probability that it resides in the Galactic bulge. This discovery represents the ninth planetary system found through microlensing with a planet orbiting a binary host. Notably, it is the first case in which the host consists of both a star and a brown dwarf. 

   more » « less