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  • In silico modelling of the effect of pyloric intervention procedures on gastric flow and emptying in a stomach with gastroparesis
Title: In silico modelling of the effect of pyloric intervention procedures on gastric flow and emptying in a stomach with gastroparesis
Pyloric interventions are surgical procedures employed to increase the gastric emptying rate in gastroparesis patients. In this study, we use anin silicomodel to investigate the consequences of pyloric intervention on gastric flow and emptying for two phenotypes of gastroparesis: antral hypomotility and decreased gastric tone. The transpyloric pressure gradient predicted by thein silicomodel, based on viscous fluid flow equations, is compared againstin vivomeasurements. Both phenotypes exhibit a similar pre-procedural emptying rate reduction, but after pyloric surgery, antral hypomotility case with preserved gastric tone shows significant improvements in emptying rates, up to 131%, accompanied by bile reflux from the duodenum into the stomach. Conversely, severely reduced gastric tone cases exhibited a post-procedural reduction in the net emptying rate due to the relatively larger bile reflux. In cases with a combination of antral hypomotility and reduced gastric tone, post-procedural improvements were observed only when both conditions were mild. Our findings highlight the pivotal role of the relative increase in pyloric orifice diameter in determining post-operative emptying rates. The study suggests a possible explanation for the selective response of patients toward these procedures and underscores the potential ofin silicomodelling to generate valuable insights to inform gastric surgery.  more » « less
Award ID(s):
2019405
PAR ID:
10511192
Author(s) / Creator(s):
; ; ;
Publisher / Repository:
Royal Society Publishing
Date Published:
Journal Name:
Journal of The Royal Society Interface
Volume:
21
Issue:
210
ISSN:
1742-5662
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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