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Protocol to implement a computational pipeline for biomedical discovery based on a biomedical knowledge graph
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Abstract Clinical, biomedical, and translational science has reached an inflection point in the breadth and diversity of available data and the potential impact of such data to improve human health and well‐being. However, the data are often siloed, disorganized, and not broadly accessible due to discipline‐specific differences in terminology and representation. To address these challenges, the Biomedical Data Translator Consortium has developed and tested a pilot knowledge graph‐based “Translator” system capable of integrating existing biomedical data sets and “translating” those data into insights intended to augment human reasoning and accelerate translational science. Having demonstrated feasibility of the Translator system, the Translator program has since moved into development, and the Translator Consortium has made significant progress in the research, design, and implementation of an operational system. Herein, we describe the current system’s architecture, performance, and quality of results. We apply Translator to several real‐world use cases developed in collaboration with subject‐matter experts. Finally, we discuss the scientific and technical features of Translator and compare those features to other state‐of‐the‐art, biomedical graph‐based question‐answering systems.more » « less
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This study aimed to provide a review of the current status of the biomimetic adhesives that have the potential for clinical application. Biomimetic materials emulate compounds and properties with a biological origin. They have grown to be more relevant in medical fields due to biocompatibility, low toxicity, and a less damaging impact on the environment. Bonding living tissues has proved to be difficult due to the adverse immune reactions to foreign materials and the wet environment of the damaged area. There is a need for biomimetic adhesives due to the shortcomings of synthetic adhesives and metal tools required for wound closure. Despite differences in developmental approaches and organismal properties, the biomimetic adhesives developed have the potential to be used in wet environments with enough strength to help bond the tissues together without any supporting materials.more » « less
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.1016/j.xpro.2023.102666
