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Title: Early and enduring: Targeting the endothelium for blood-brain barrier protection
The disruption of the blood-brain barrier marks a pivotal early pathological event in ischemic stroke that significantly contributes to subsequent permanent damage. Here we delve into the ramifications of a study conducted by Xu and colleagues, which underscores the essential role of the protein peroxiredoxin-4 in cerebrovascular endothelial cells. Peroxiredoxin-4 was shown to preserve blood-brain barrier integrity during the early stages after cerebral ischemia and reperfusion, ultimately leading to improved long-term outcomes.  more » « less
Award ID(s):
1916894
PAR ID:
10523787
Author(s) / Creator(s):
; ;
Publisher / Repository:
Sage Journals
Date Published:
Journal Name:
Journal of Cerebral Blood Flow & Metabolism
ISSN:
0271-678X
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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