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As the most lethal major cancer, pancreatic cancer is a global healthcare challenge. Personalized medicine utilizing cutting-edge multi-omics data holds potential for major breakthroughs in tackling this critical problem. Radiomics and deep learning, two trendy quantitative imaging methods that take advantage of data science and modern medical imaging, have shown increasing promise in advancing the precision management of pancreatic cancer via diagnosing of precursor diseases, early detection, accurate diagnosis, and treatment personalization and optimization. Radiomics employs manually-crafted features, while deep learning applies computer-generated automatic features. These two methods aim to mine hidden information in medical images that is missed by conventional radiology and gain insights by systematically comparing the quantitative image information across different patients in order to characterize unique imaging phenotypes. Both methods have been studied and applied in various pancreatic cancer clinical applications. In this review, we begin with an introduction to the clinical problems and the technology. After providing technical overviews of the two methods, this review focuses on the current progress of clinical applications in precancerous lesion diagnosis, pancreatic cancer detection and diagnosis, prognosis prediction, treatment stratification, and radiogenomics. The limitations of current studies and methods are discussed, along with future directions. With better standardization and optimization of the workflow from image acquisition to analysis and with larger and especially prospective high-quality datasets, radiomics and deep learning methods could show real hope in the battle against pancreatic cancer through big data-based high-precision personalization.
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Efficient System Design for Next Generation of Medical Imaging for Skin Cancer Detection
Abstract— Recent advances show the wide-ranging applications of machine learning for solving multi-disciplinary problems in cancer cell growth detection, modeling cancer growths and treatments, etc. There is growing interests among the faculty and students at Clayton State University to study the applications of machine learning for medical imaging and propose new algorithms based on a recently funded NSF grant proposal in medical imaging, skin cancer detection, and associated smartphone apps and a web-based user-friendly diagnosis interface. We tested many available open-source ML algorithm-based software sets in Python as applied to medical image data processing, and modeling used to predict cancer growths and treatments. We study the use of ML concepts that promote efficient, accurate, secure computation over medical images, identifying and classifying cancer cells, and modeling the cancer cell growths. In this collaborative project with another university, we follow a holistic approach to data analysis leading to more efficient cancer detection based upon both cell analysis and image recognition. Here, we compare ML based software methods and analyze their detection accuracy. In addition, we acquire publicly available data of cancer cell image files and analyze using deep learning algorithms to detect benign and suspicious image samples. We apply the current pattern matching algorithms and study the available data with possible diagnosis of cancer types.
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- Award ID(s):
- 2318574
- PAR ID:
- 10524530
- Publisher / Repository:
- R Plus: International Conference on Advanced Cancer Detection and Radiology Research (ICACDRR-24)
- Date Published:
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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Accepted Manuscript1.0
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- The DOI is not currently available.
