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1. Frequency-specific neural signatures of perceptual content and perceptual stability

   https://doi.org/10.7554/eLife.78108  

   Hardstone, Richard; Flounders, Matthew W; Zhu, Michael; He, Biyu J (September 2022, eLife)

   In the natural environment, we often form stable perceptual experiences from ambiguous and fleeting sensory inputs. Which neural activity underlies the content of perception and which neural activity supports perceptual stability remains an open question. We used a bistable perception paradigm involving ambiguous images to behaviorally dissociate perceptual content from perceptual stability, and magnetoencephalography to measure whole-brain neural dynamics in humans. Combining multivariate decoding and neural state-space analyses, we found frequency-band-specific neural signatures that underlie the content of perception and promote perceptual stability, respectively. Across different types of images, non-oscillatory neural activity in the slow cortical potential (<5 Hz) range supported the content of perception. Perceptual stability was additionally influenced by the amplitude of alpha and beta oscillations. In addition, neural activity underlying perceptual memory, which supports perceptual stability when sensory input is temporally removed from view, also encodes elapsed time. Together, these results reveal distinct neural mechanisms that support the content versus stability of visual perception. 

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2. Modeling and dissociation of intrinsic and input-driven neural population dynamics underlying behavior

   https://doi.org/10.1073/pnas.2212887121  

   Vahidi, Parsa; Sani, Omid G; Shanechi, Maryam M (February 2024, Proceedings of the National Academy of Sciences)

   Neural dynamics can reflect intrinsic dynamics or dynamic inputs, such as sensory inputs or inputs from other brain regions. To avoid misinterpreting temporally structured inputs as intrinsic dynamics, dynamical models of neural activity should account for measured inputs. However, incorporating measured inputs remains elusive in joint dynamical modeling of neural-behavioral data, which is important for studying neural computations of behavior. We first show how training dynamical models of neural activity while considering behavior but not input or input but not behavior may lead to misinterpretations. We then develop an analytical learning method for linear dynamical models that simultaneously accounts for neural activity, behavior, and measured inputs. The method provides the capability to prioritize the learning of intrinsic behaviorally relevant neural dynamics and dissociate them from both other intrinsic dynamics and measured input dynamics. In data from a simulated brain with fixed intrinsic dynamics that performs different tasks, the method correctly finds the same intrinsic dynamics regardless of the task while other methods can be influenced by the task. In neural datasets from three subjects performing two different motor tasks with task instruction sensory inputs, the method reveals low-dimensional intrinsic neural dynamics that are missed by other methods and are more predictive of behavior and/or neural activity. The method also uniquely finds that the intrinsic behaviorally relevant neural dynamics are largely similar across the different subjects and tasks, whereas the overall neural dynamics are not. These input-driven dynamical models of neural-behavioral data can uncover intrinsic dynamics that may otherwise be missed. 

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3. Input correlations impede suppression of chaos and learning in balanced firing-rate networks

   https://doi.org/10.1371/journal.pcbi.1010590  

   Engelken, Rainer; Ingrosso, Alessandro; Khajeh, Ramin; Goedeke, Sven; Abbott, L. F. (December 2022, PLOS Computational Biology)

   Aljadeff, Johnatan (Ed.)

   Neural circuits exhibit complex activity patterns, both spontaneously and evoked by external stimuli. Information encoding and learning in neural circuits depend on how well time-varying stimuli can control spontaneous network activity. We show that in firing-rate networks in the balanced state, external control of recurrent dynamics, i.e., the suppression of internally-generated chaotic variability, strongly depends on correlations in the input. A distinctive feature of balanced networks is that, because common external input is dynamically canceled by recurrent feedback, it is far more difficult to suppress chaos with common input into each neuron than through independent input. To study this phenomenon, we develop a non-stationary dynamic mean-field theory for driven networks. The theory explains how the activity statistics and the largest Lyapunov exponent depend on the frequency and amplitude of the input, recurrent coupling strength, and network size, for both common and independent input. We further show that uncorrelated inputs facilitate learning in balanced networks. 

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4. Robust computation with rhythmic spike patterns

   https://doi.org/10.1073/pnas.1902653116  

   Frady, E. Paxon; Sommer, Friedrich T. (August 2019, Proceedings of the National Academy of Sciences)

   Information coding by precise timing of spikes can be faster and more energy efficient than traditional rate coding. However, spike-timing codes are often brittle, which has limited their use in theoretical neuroscience and computing applications. Here, we propose a type of attractor neural network in complex state space and show how it can be leveraged to construct spiking neural networks with robust computational properties through a phase-to-timing mapping. Building on Hebbian neural associative memories, like Hopfield networks, we first propose threshold phasor associative memory (TPAM) networks. Complex phasor patterns whose components can assume continuous-valued phase angles and binary magnitudes can be stored and retrieved as stable fixed points in the network dynamics. TPAM achieves high memory capacity when storing sparse phasor patterns, and we derive the energy function that governs its fixed-point attractor dynamics. Second, we construct 2 spiking neural networks to approximate the complex algebraic computations in TPAM, a reductionist model with resonate-and-fire neurons and a biologically plausible network of integrate-and-fire neurons with synaptic delays and recurrently connected inhibitory interneurons. The fixed points of TPAM correspond to stable periodic states of precisely timed spiking activity that are robust to perturbation. The link established between rhythmic firing patterns and complex attractor dynamics has implications for the interpretation of spike patterns seen in neuroscience and can serve as a framework for computation in emerging neuromorphic devices. 

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5. Short-term solar irradiance forecasting under data transmission constraints

   https://doi.org/10.1016/j.renene.2024.121058  

   Hammond, Joshua E; Lara_Orozco, Ricardo A; Baldea, Michael; Korgel, Brian A (October 2024, Renewable Energy)

   We report a data-parsimonious machine learning model for short-term forecasting of solar irradiance. The model follows the convolutional neural network – long-short term memory architecture. Its inputs include sky camera images that are reduced to scalar features to meet data transmission constraints. The model focuses on predicting the deviation of irradiance from the persistence of cloudiness (POC) model. Inspired by control theory, a noise signal input is used to capture the presence of unknown and/or unmeasured input variables and is shown to improve model predictions, often considerably. Five years of data from the NREL Solar Radiation Research Laboratory were used to create three rolling train-validate sets and determine the best representations for time, the optimal span of input measurements, and the most impactful model input data (features). For the chosen validation data, the model achieves a mean absolute error of 74.29 W/m2 over a time horizon of up to two hours, compared to a baseline 134.35 W/m2 using the POC model. 

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