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  • The stem cell niche transcription factor ETHYLENE RESPONSE FACTOR 115 participates in aluminum‐induced terminal differentiation in Arabidopsis roots
Title: The stem cell niche transcription factor ETHYLENE RESPONSE FACTOR 115 participates in aluminum‐induced terminal differentiation in Arabidopsis roots
Abstract Aluminum‐dependent stoppage of root growth requires the DNA damage response (DDR) pathway including the p53‐like transcription factor SUPPRESSOR OF GAMMA RADIATION 1 (SOG1), which promotes terminal differentiation of the root tip in response to Al dependent cell death. Transcriptomic analyses identified Al‐induced SOG1‐regulated targets as candidate mediators of this growth arrest. Analysis of these factors either as loss‐of‐function mutants or by overexpression in theals3‐1background shows ERF115, which is a key transcription factor that in other scenarios is rate‐limiting for damaged stem cell replenishment, instead participates in transition from an actively growing root to one that has terminally differentiated in response to Al toxicity. This is supported by a loss‐of‐functionerf115mutant raising the threshold of Al required to promote terminal differentiation of Al hypersensitiveals3‐1. Consistent with its key role in stoppage of root growth, a putativeERF115barley ortholog is also upregulated following Al exposure, suggesting a conserved role for this ATR‐dependent pathway in Al response. In contrast to other DNA damage agents, these results show that ERF115 and likely related family members are important determinants of terminal differentiation of the root tip following Al exposure and central outputs of the SOG1‐mediated pathway in Al response.  more » « less
Award ID(s):
2215705
PAR ID:
10535052
Author(s) / Creator(s):
; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
Publisher / Repository:
Nature Portfolio
Date Published:
Journal Name:
Plant, Cell & Environment
ISSN:
0140-7791
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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