ABSTRACT ObjectiveNeighborhood perceptions are associated with physical and mental health outcomes; however, the biological associates of this relationship remain to be fully understood. Here, we evaluate the relationship between neighborhood perceptions and amygdala activity and connectivity with salience network (i.e., insula, anterior cingulate, thalamus) nodes. MethodsForty-eight older adults (mean age = 68 [7] years, 52% female, 47% non-Hispanic Black, 2% Hispanic) without dementia or depression completed the Perceptions of Neighborhood Environment Scale. Lower scores indicated less favorable perceptions of aesthetic quality, walking environment, availability of healthy food, safety, violence (i.e., more perceived violence), social cohesion, and participation in activities with neighbors. Participants separately underwent resting-state functional magnetic resonance imaging. ResultsLess favorable perceived safety (β= −0.33,pFDR= .04) and participation in activities with neighbors (β= −0.35,pFDR= .02) were associated with higher left amygdala activity, independent of covariates including psychosocial factors. Less favorable safety perceptions were also associated with enhanced left amygdala functional connectivity with the bilateral insular cortices and the left anterior insula (β= −0.34,pFDR= .04). Less favorable perceived social cohesion was associated with enhanced left amygdala functional connectivity with the right thalamus (β =−0.42,pFDR= .04), and less favorable perceptions about healthy food availability were associated with enhanced left amygdala functional connectivity with the bilateral anterior insula (right:β= −0.39,pFDR= .04; left:β= −0.42,pFDR= .02) and anterior cingulate gyrus (β= −0.37,pFDR= .04). ConclusionsTaken together, our findings document relationships between select neighborhood perceptions and amygdala activity as well as connectivity with salience network nodes; if confirmed, targeted community-level interventions and existing community strengths may promote brain-behavior relationships.
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Interventions to Mitigate Fatigue Induced by Physical Work: A Systematic Review of Research Quality and Levels of Evidence for Intervention Efficacy
ObjectiveWe present a literature review on workplace physical fatigue interventions, focusing on evaluating the methodological quality and strength of evidence. BackgroundPhysical fatigue is a recognized workplace problem, with negative effects on performance and health-related complaints. Although many studies have focused on the mechanisms and consequences of fatigue, few have considered the effectiveness of interventions to mitigate fatigue. MethodA systematic review of the workplace safety literature for controlled trials of physical fatigue interventions was conducted. Data on intervention type, subject characteristics, targeted tasks and body locations, outcome measures, and study design were extracted. The methodological quality for each study was evaluated using the PEDro scale, and the level of evidence was based on quality, amount, and consistency. ResultsForty-five controlled trials were reviewed, examining 18 interventions. We categorized those interventions into individual-focused (N= 28 studies, nine interventions), workplace-focused (N= 12 studies, five interventions), and multiple interventions (N= 5 studies, four interventions). We identified moderate evidence for interventions related to assistive devices and task variation. There was moderate evidence supporting no fatigue attenuation for the garment change category of interventions. The interventions in the remaining categories had limited to minimal evidence of efficacy. The heterogeneity of the included trials precludes the determination of effect size. ConclusionThis review showed a lack of high levels of evidence for the effectiveness of most physical fatigue interventions. ApplicationDue to a lack of high levels of evidence for any category of reviewed physical fatigue interventions, further high-quality studies are needed to establish the efficacy of others.
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- Award ID(s):
- 1635927
- PAR ID:
- 10546882
- Publisher / Repository:
- SAGE Publications
- Date Published:
- Journal Name:
- Human Factors: The Journal of the Human Factors and Ergonomics Society
- Volume:
- 63
- Issue:
- 1
- ISSN:
- 0018-7208
- Format(s):
- Medium: X Size: p. 151-191
- Size(s):
- p. 151-191
- Sponsoring Org:
- National Science Foundation
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