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Title: Handling fluorinated gases as solid reagents using metal-organic frameworks
Fluorine is an increasingly common substituent in pharmaceuticals and agrochemicals because it improves the bioavailability and metabolic stability of organic molecules. Fluorinated gases represent intuitive building blocks for the late-stage installation of fluorinated groups, but they are generally overlooked because they require the use of specialized equipment. We report a general strategy for handling fluorinated gases as benchtop-stable solid reagents using metal-organic frameworks (MOFs). Gas-MOF reagents are prepared on gram-scale and used to facilitate fluorovinylation and fluoroalkylation reactions. Encapsulation of gas-MOF reagents within wax enables stable storage on the benchtop and controlled release into solution upon sonication, which represents a safer alternative to handling the gas directly. Furthermore, our approach enables high-throughput reaction development with these gases.  more » « less
Award ID(s):
1719875
PAR ID:
10548659
Author(s) / Creator(s):
; ; ; ; ; ; ;
Publisher / Repository:
AAAS
Date Published:
Journal Name:
Science
Volume:
381
Issue:
6665
ISSN:
0036-8075
Page Range / eLocation ID:
1455 to 1461
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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