Semantic structures facilitate threat memory integration throughout the medial temporal lobe and medial prefrontal cortex

Cooper, Samuel E; Hennings, Augustin C; Bibb, Sophia A; Lewis-Peacock, Jarrod A; Dunsmoor, Joseph E

doi:10.1016/j.cub.2024.06.071

Abstract Recently proposed as a stable means of evaluating geometric compactness, theisoperimetric profileof a planar domain measures the minimum perimeter needed to inscribe a shape with prescribed area varying from 0 to the area of the domain. While this profile has proven valuable for evaluating properties of geographic partitions, existing algorithms for its computation rely on aggressive approximations and are still computationally expensive. In this paper, we propose a practical means of approximating the isoperimetric profile and show that for domains satisfying a“thick neck”condition, our approximation is exact. For more general domains, we show that our bound is still exact within a conservative regime and is otherwise an upper bound. Our method is based on a traversal of the medial axis which produces efficient and robust results. We compare our technique with the state‐of‐the‐art approximation to the isoperimetric profile on a variety of domains and show significantly tighter bounds than were previously achievable.

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